Prof. dr. Lucija Peterlin Mašič, mag. farm.

Teaching activities:

• Uniform master’s study programme Pharmacy 5+0: Psychotropic Drugs and Drug Abuse, Quality of Drugs and Toxicological Chemistry; 
• University study programme Laboratory Biomedicine 3+: Psychotropic Drugs and Drug Abuse;
• University study programme Cosmetology 3+: Toxicology of Cosmetic ingredients;
• Master’s study programme Industrial Pharmacy, +2: Biological and Toxicological Properties of Pharmaceutical Excipients;
• Master’s study programme Industrial Pharmacy, +2: Toxicology;
• PhD study of Biomedicine: coordinator of Module 1.3 Drug Design Methodologies.

Publications:

2020:

• ZIDAR, Nace, SECCI, Daniela, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, 1. ZIDAR, Nace, SECCI, Daniela, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, PASSARELLA, Daniele, ARGAEZ, Aida Nelly Garcia, HYERACI, Mariafrancesca, VIA DALLA, Lisa, CARPINELLA, María Cecilia. Synthesis, antiproliferative effect and topoisomerase II inhibitory activity of 3-methyl-2-phenyl-1H-indoles. ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2020, vol. , iss. , str., ilustr. https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00557, https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00557, doi: 10.1021/acsmedchemlett.9b00557. [COBISS.SI-ID 4874609
• LAMUT, Andraž, DURANTE CRUZ, Cristina, SKOK, Žiga, BARANČOKOVA, Michaela, ZIDAR, Nace, ZEGA, Anamarija, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez, TAMMELA, Päivi, KIKELJ, Danijel, TOMAŠIČ, Tihomir. Design, synthesis and biological evaluation of novel DNA gyrase inhibitorsand their siderophore mimic conjugates. Bioorganic chemistry, ISSN 0045-2068, 2020, vol. 95, str. 1-13, ilustr. https://www.sciencedirect.com/science/article/pii/S0045206819316591?dgcid=author, doi: 10.1016/j.bioorg.2019.103550. [COBISS.SI-ID 4865137]
• GATTA, Viviana, TOMAŠIČ, Tihomir, ILAŠ, Janez, ZIDAR, Nace, PETERLIN-MAŠIČ, Lucija, BARANČOKOVA, Michaela, FRLAN, Rok, ANDERLUH, Marko, KIKELJ, Danijel, TAMMELA, Päivi. A new cell-based AI-2-mediated quorum sensing interference assay in screening of LsrK-targeted inhibitors. ChemBioChem, ISSN 1439-7633, 2020, vol. , iss. , str., ilustr. https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201900773, doi: 10.1002/cbic.201900773. [COBISS.SI-ID 4879729]
• FOIS, Benedetta, SKOK, Žiga, TOMAŠIČ, Tihomir, ILAŠ, Janez, ZIDAR, Nace, ZEGA, Anamarija, PETERLIN-MAŠIČ, Lucija, SZILI, Petra, DRASKOVITS, Gábor, NYERGES JÓZSEF, Ákos, PÁL, Csaba, KIKELJ, Danijel. Dual Escherichia coli DNA gyrase A and B inhibitors with antibacterial activity. ChemMedChem, ISSN 1860-7187, 2020, vol. 15, iss. 3, str. 265-269, ilustr. https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900607, doi: 10.1002/cmdc.201900607. [COBISS.SI-ID 4865393]
• GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija. In vitro estrogenic activity of binary and multicomponent mixtures with bisphenol A. Science of the total environment, ISSN 0048-9697, 2020, letn. 707, str. 1-10, ilustr. https://www.sciencedirect.com/science/article/pii/S0048969719352039?via%3Dihub, doi: 10.1016/j.scitotenv.2019.135211. [COBISS.SI-ID 4857457]
• GRAMEC, Darja, TVRDÝ, Václav, KENDA, Maša, ZEGA, Anamarija, POUR, Milan, HORKÝ, Pavel, PŘEMYSL, Mladěnka, SOLLNER DOLENC, Marija, PETERLIN-MAŠIČ, Lucija. Applicability of the OECD 455 in - vitro assay for determination of hERa agonistic activity of isoflavonoids. Toxicology and applied pharmacology, ISSN 0041-008X, Jan. 2020, vol. 386, str. 1-9, ilustr., graf. prikazi. https://www.sciencedirect.com/science/article/pii/S0041008X19304399?via%3Dihub, doi: 10.1016/j.taap.2019.114831. [COBISS.SI-ID 4851825]

2019:

• GRAMEC, Darja, CARINO, Adriana, TRONTELJ, Jurij, TROBERG, Johanna, DISTRUTTI, Eleonora, MARCHIANÒ, Silvia, TOMAŠIČ, Tihomir, ZEGA, Anamarija, FINEL, Moshe, FIORUCCI, Stefano, PETERLIN-MAŠIČ, Lucija. Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite. Chemosphere, ISSN 0045-6535. [Print ed.], Jan. 2019, vol. 215, str. 870-880, ilustr. https://www.sciencedirect.com/science/article/pii/S0045653518319908#!, doi: 10.1016/j.chemosphere.2018.10.129. [COBISS.SI-ID 4620401]
• GRAMEC, Darja, TOMAŠIČ, Tihomir, SOLLNER DOLENC, Marija, PETERLIN-MAŠIČ, Lucija, ZEGA, Anamarija. Evaluation of endocrine activities of ellagic acid and urolithins using reporter gene assays. Chemosphere, ISSN 0045-6535. [Print ed.], Apr. 2019, vol. 220, str. 706-713, graf. prikazi. https://www.sciencedirect.com/science/article/pii/S0045653518325268?via%3Dihub, doi: 10.1016/j.chemosphere.2018.12.185. [COBISS.SI-ID 4654961]
• BENEDETTO TIZ, Davide, SKOK, Žiga, DURCIK, Martina, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez, ZEGA, Anamarija, DRASKOVITS, Gábor, REVESZ, T., NYERGES JÓZSEF, Ákos, PÁL, Csaba, DURANTE CRUZ, Cristina, TAMMELA, Päivi, ŽIGON, Dušan, KIKELJ, Danijel, ZIDAR, Nace. An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors. European Journal of Medicinal Chemistry, ISSN 0223-5234. [Print ed.], Apr. 2019, vol. 167, str. 269-290, ilustr. https://www.sciencedirect.com/science/article/pii/S022352341930114X?via%3Dihub#!, doi: 10.1016/j.ejmech.2019.02.004. [COBISS.SI-ID 4686961]
• ZIDAR, Nace, MACUT, Helena, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez, ZEGA, Anamarija, TAMMELA, Päivi, KIKELJ, Danijel. New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors. MedChemComm, ISSN 2040-2503, 2019, vol. 10, iss. 6, str. 1007-1017, ilustr. https://pubs.rsc.org/en/content/articlelanding/2019/md/c9md00224c#!divAbstract, https://pubs.rsc.org/en/content/articlepdf/2019/md/c9md00224c?page=search, doi: 10.1039/C9MD00224C. [COBISS.SI-ID 4724337]

 2018:

• LAIOLO, Jeronimo, TOMAŠIČ, Tihomir, VERA, D. Mariano A., GONZÁLEZ L., María L, LANZA A., Priscila, GANCEDO N., Samanta, HODNIK, Žiga, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, CARPINELLA, María Cecilia. Analogs of the lignan pinoresinol as novel lead compounds for P-glycoprotein (P-gp) inhibitors. ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2018, vol. 9, iss. 12, str. 1186-1192, ilustr. https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00324, doi: 10.1021/acsmedchemlett.8b00324. [COBISS.SI-ID 4642161]
• KARRER, Cecile, ROISS, Thomas, GOETZ VON, Natalie, GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija, HUNGERBÜHLER, Konrad. Physiologically based pharmacokinetic PBPK modelling of bisphenol BPA, BPS, BPF, and BPAF with new experimental metabolic parametrics : comparing the pharmacokinetic behavior of BPA with its substitutes. Environmental health perspectives, ISSN 1552-9924, Jul. 2018, vol. 126, iss. 7, str. 077002-1 - 077002-17. https://ehp.niehs.nih.gov/ehp2739/, https://ehp.niehs.nih.gov/pub/126-7/, doi: 10.1289/EHP2739. [COBISS.SI-ID 4523889]
• DURCIK, Martina, LOVISON, Denise, SKOK, Žiga, DURANTE CRUZ, Cristina, TAMMELA, Päivi, TOMAŠIČ, Tihomir, BENEDETTO TIZ, Davide, DRASKOVITS, Gábor, NYERGES, Ákos, PÁL, Csaba, ILAŠ, Janez, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, ZIDAR, Nace. New N-phenylpyrrolamide DNA gyrase B inhibitors : optimisation of efficacy and antibacterial activity. European Journal of Medicinal Chemistry, ISSN 0223-5234. [Print ed.], June 2018, vol. 154, str. 117-132, ilustr. https://www.sciencedirect.com/science/article/pii/S022352341830415X, doi: 10.1016/j.ejmech.2018.05.011. [COBISS.SI-ID 4504945]

2017:

• COTMAN, Andrej Emanuel, TRAMPUŽ, Marko, BRVAR, Matjaž, KIKELJ, Danijel, ILAŠ, Janez, PETERLIN-MAŠIČ, Lucija, MONTALVÃO, Sofia, TAMMELA, Päivi, FRLAN, Rok. Design, synthesis, and evaluation of novel tyrosine-based DNA gyrase B inhibitors. Archiv der Pharmazie, ISSN 1521-4184, Aug. 2017, vol. 350, iss. 8, str. e1700087-1-e1700087-16. http://onlinelibrary.wiley.com/doi/10.1002/ardp.201700087/epdf, doi: 10.1002/ardp.201700087. [COBISS.SI-ID 6206746]
• ZIDAR, Nace, ŽULA, Aleš, TOMAŠIČ, Tihomir, ROGERS, Marc, KIRBY, Robert W., TYTGAT, Jan, PEIGNEUR, Steve, KIKELJ, Danijel, ILAŠ, Janez, PETERLIN-MAŠIČ, Lucija. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. European Journal of Medicinal Chemistry, ISSN 0223-5234. [Print ed.], Oct. 2017, vol. 139, str. 232-241, ilustr. http://www.sciencedirect.com/science/article/pii/S0223523417306189, doi: 10.1016/j.ejmech.2017.08.015. [COBISS.SI-ID 4360049]

2016:

• GRAMEC, Darja, SCHMIDT, Jan, FIC, Anja, KLOPČIČ, Ivana, TRONTELJ, Jurij, SOLLNER DOLENC, Marija, FINEL, Moshe, PETERLIN-MAŠIČ, Lucija. Influence of metabolism on endocrine activities of bisphenol S. Chemosphere, ISSN 0045-6535. [Print ed.], 2016, vol. 157, str. 152-159, ilustr. http://www.sciencedirect.com/science/article/pii/S004565351630666X, doi: 10.1016/j.chemosphere.2016.05.027. [COBISS.SI-ID 4085105]
• KLOPČIČ, Ivana, GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija, SOLLNER DOLENC, Marija. Comparison of in vitro hormone activities of novel flame retardants TBB, TBPH and their metabolites TBBA and TBMEPH using reporter gene assays. Chemosphere, ISSN 0045-6535. [Print ed.], Oct. 2016, vol. 160, str. 244-251, ilustr., graf. prikazi. http://www.sciencedirect.com/science/article/pii/S0045653516308499, doi: 10.1016/j.chemosphere.2016.06.091. [COBISS.SI-ID 4118897]
• GJORGJIEVA, Marina, TOMAŠIČ, Tihomir, BARANČOKOVA, Michaela, KATSAMAKAS, Sotirios, ILAŠ, Janez, TAMMELA, Päivi, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors. Journal of medicinal chemistry, ISSN 0022-2623, 2016, vol. 59, iss. 19, str. 8941-8954, ilustr. http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00864, doi: 10.1021/acs.jmedchem.6b00864. [COBISS.SI-ID 4145265]
• NABERGOJ, Dominik, VRBEK, Sanja, ZIDAR, Nace, TOMAŠIČ, Tihomir, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija, MULLER, Christian D. Synthetic analogues of marine alkaloid clathrodin differently induce phosphatidylserine exposure in monocytic cancer cell then in cancer stem cell lines. MedChemComm, ISSN 2040-2503, 2016, vol. 7, iss. 8, str. 1546-1554, ilustr. http://pubs.rsc.org/en/content/articlelanding/2016/md/c6md00163g#!divAbstract, http://pubs.rsc.org/en/content/articlepdf/2016/md/c6md00163g, doi: 10.1039/C6MD00163G. [COBISS.SI-ID 4079473]
• BENÍTEZ, Diego, MEDEIROS, Andrea, PANOZZO-ZENERE, Esteban A., PROUSIS, Kyriakos C., ROUSSAKI, Marina, CALOGEROPOULOU, Theodora, DETSI, Anastasia, JAEGER, Timo, ŠARALUSKAS, Jonas, PETERLIN-MAŠIČ, Lucija, KUNICK, Conrad, LABADIE, Guillermo R., FLOHÉ, Leopold, COMINI, Marcelo A. Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids. PLoS neglected tropical diseases, ISSN 1935-2735, Apr. 2016, vol. 10, iss. 4, str. 1-25, ilustr. http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004617, doi: 10.1371/journal.pntd.0004617. [COBISS.SI-ID 4130673]
• GRAMEC, Darja, TOMAŠIČ, Tihomir, CARINO, Adriana, DISTRUTTI, Eleonora, FIORUCCI, Stefano, PETERLIN-MAŠIČ, Lucija. New brominated flame retardants and their metabolites as activators of the pregnane X receptor. Toxicology letters, ISSN 0378-4274. [Print ed.], 2016, vol. 259, str. 116-123, ilustr. http://www.sciencedirect.com/science/article/pii/S0378427416330922, doi: 10.1016/j.toxlet.2016.08.005. [COBISS.SI-ID 4142961]

2015:

• HODNIK, Žiga, TOMAŠIČ, Tihomir, SMODIŠ, Domen, D'AMORE, Claudio, PETERLIN-MAŠIČ, Lucija, FIORUCCI, Stefano, KIKELJ, Danijel. Diethylstilbestrol-scaffold-based pregnane X receptor modulators. European Journal of Medicinal Chemistry, ISSN 0223-5234. [Print ed.], Oct. 2015, vol. 103, str. 551-562, ilustr. http://www.sciencedirect.com/science/article/pii/S022352341530249X, doi: 10.1016/j.ejmech.2015.09.005. [COBISS.SI-ID 3921009]
• TOMAŠIČ, Tihomir, KATSAMAKAS, Sotirios, HODNIK, Žiga, ILAŠ, Janez, BRVAR, Matjaž, ŠOLMAJER, Tomaž, MONTALVÃO, Sofia, TAMMELA, Päivi, BANJANAC, Mihailo, ERGOVIĆ, Gabrijela, ANDERLUH, Marko, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Discovery of 4,5,6,7-tetrahydrobenzo[1, 2-d]thiazoles as novel DNA gyrase inhibitors targeting the ATP-binding site. Journal of medicinal chemistry, ISSN 0022-2623, 2015, vol. 58, iss. 14, str. 5501-521, ilustr. http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00489, doi: 10.1021/acs.jmedchem.5b00489. [COBISS.SI-ID 3889009]
• ZIDAR, Nace, MACUT, Helena, TOMAŠIČ, Tihomir, BRVAR, Matjaž, MONTALVÃO, Sofia, TAMMELA, Päivi, ŠOLMAJER, Tomaž, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez, KIKELJ, Danijel. N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATP competitive DNA gyrase B inhibitors : design, synthesis, and evaluation. Journal of medicinal chemistry, ISSN 0022-2623, 2015, vol. 58, iss. 15, str. 6179-6194, ilustr. http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00775, doi: 10.1021/acs.jmedchem.5b00775. [COBISS.SI-ID 3888753]
• TOMAŠIČ, Tihomir, NABERGOJ, Dominik, VRBEK, Sanja, ZIDAR, Nace, JAKOPIN, Žiga, ŽULA, Aleš, HODNIK, Žiga, JUKIČ, Marko, ANDERLUH, Marko, ILAŠ, Janez, SOLLNER DOLENC, Marija, PELUSO, Jean, UBEAUD-SÉQUIER, Geneviève, MULLER, Christian D., PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells. MedChemComm, ISSN 2040-2503, 2015, vol. 6, iss. 1, str. 105-110, ilustr. http://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00286e#!divAbstract, http://pubs.rsc.org/en/content/articlepdf/2015/md/c4md00286e, doi: 10.1039/C4MD00286E. [COBISS.SI-ID 3697265]
• FIC, Anja, JURKOVIĆ MLAKAR, Simona, JUVAN, Peter, MLAKAR, Vid, MARC, Janja, SOLLNER DOLENC, Marija, BROBERK, Karin, PETERLIN-MAŠIČ, Lucija. Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicology in vitro, ISSN 0887-2333, Apr. 2015, vol. 29, iss. 5, str. 1060-1069. http://www.sciencedirect.com/science/article/pii/S0887233315000557#, doi: 10.1016/j.tiv.2015.03.014. [COBISS.SI-ID 3849841]
• GRAMEC, Darja, TROBERG, Johanna, JAVDAS, Jason, PETERLIN-MAŠIČ, Lucija, FINEL, Moshe. Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10. Xenobiotica, ISSN 0049-8254, 2015, vol. 45, iss. 6, str. 511-519, ilustr. http://informahealthcare.com/doi/abs/10.3109/00498254.2014.999140, doi: 10.3109/00498254.2014.999140. [COBISS.SI-ID 3835505]

2014:

• ARSOVSKA, Emilija, TRONTELJ, Jurij, ZIDAR, Nace, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, PLAVEC, Janez, ZEGA, Anamarija. Evaluation of Michael-type acceptor reactivity of 5-benzylidenebarbiturates, 5-benzylidenerhodanines, and related heterocycles using NMR. Acta chimica slovenica, ISSN 1318-0207. [Tiskana izd.], 2014, vol. 61, no. 3, str. 637-644. [COBISS.SI-ID 5563162]
• HODNIK, Žiga, ŁOŚ, Joanna M., ŽULA, Aleš, ZIDAR, Nace, JAKOPIN, Žiga, ŁOŚ, Marcin, SOLLNER DOLENC, Marija, ILAŠ, Janez, WĘGRZYN, Grzegorz, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin. Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X. [Print ed.], 2014, vol. 24, iss. 11, str. 2530-2534, ilustr. http://www.sciencedirect.com/science/article/pii/S0960894X14003308#, http://ac.els-cdn.com/S0960894X14003308/1-s2.0-S0960894X14003308-main. pdf?_tid=cf3393a2-fd02-11e3-a6ec-00000aab0f02&acdnat=1403767606_1e067a1b2ef3e7dac6b690f7924993c8, doi: 10.1016/j.bmcl.2014.03.094. [COBISS.SI-ID 3630449]
• GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija, SOLLNER DOLENC, Marija. Bioactivation potential of thiophene-containing drugs. Chemical research in toxicology, ISSN 0893-228X. [Print ed.], 2014, vol. 27, no. 8, str. 1344-1358. http://pubs.acs.org/doi/abs/10.1021/tx500134g, http://pubs.acs.org/doi/pdf/10.1021/tx500134g, doi: 10.1021/tx500134g. [COBISS.SI-ID 3690609]
• FIC, Anja, ŽEGURA, Bojana, GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija. Estrogenic and androgenic activities of TBBA and TBMEPH, metabolites of novel brominated flame retardants, and selected bisphenols, using the XenoScreen XL YES/YAS assay. Chemosphere, ISSN 0045-6535. [Print ed.], 2014, vol. 112, str. 362-369. http://www.sciencedirect.com/science/article/pii/S0045653514005906, doi: 10.1016/j.chemosphere.2014.04.080. [COBISS.SI-ID 3134799]
• ZIDAR, Nace, JAKOPIN, Žiga, MADGE, David J., CHAN, Fiona, TYTGAT, Jan, PEIGNEUR, Steve, SOLLNER DOLENC, Marija, TOMAŠIČ, Tihomir, ILAŠ, Janez, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, et al. Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2- aminoimidazoles as voltage-gated sodium channel modulators. European Journal of Medicinal Chemistry, ISSN 0223-5234. [Print ed.], 2014, vol. 74, str. 23-30, ilustr. http://www.sciencedirect.com/science/article/pii/S0223523413008222, doi: 10.1016/j.ejmech.2013.12.034. [COBISS.SI-ID 3585905]
• HODNIK, Žiga, PETERLIN-MAŠIČ, Lucija, TOMAŠIČ, Tihomir, SMODIŠ, Domen, D'AMORE, Claudio, FIORUCCI, Stefano, KIKELJ, Danijel. Bazedoxifene scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists. Journal of medicinal chemistry, ISSN 0022-2623, 2014, vol. 57, no. 11, str. 4819-4833, ilustr. http://pubs.acs.org/doi/abs/10.1021/jm500351m, doi: 10.1021/jm500351m. [COBISS.SI-ID 3647601]
• ZIDAR, Nace, MONTALVÃO, Sofia, HODNIK, Žiga, NAWROT, Dorota A., ŽULA, Aleš, ILAŠ, Janez, KIKELJ, Danijel, TAMMELA, Päivi, PETERLIN-MAŠIČ, Lucija. Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues. Marine drugs, ISSN 1660-3397, 2014, vol. 12, no. 2, str. 940-963. http://www.mdpi.com/1660-3397/12/2/940, doi: 10.3390/md12020940. [COBISS.SI-ID 3602801]

Review articles:                                                                                                                          

• DURCIK, Martina, TOMAŠIČ, Tihomir, ZIDAR, Nace, ZEGA, Anamarija, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez. ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents. Expert opinion on therapeutic patents, ISSN 1354-3776, 2019, vol. 29, iss. 3, str. 171-180, ilustr. https://www.tandfonline.com/doi/full/10.1080/13543776.2019.1575362, doi: 10.1080/13543776.2019.1575362. [COBISS.SI-ID 4684145]
• LAMUT, Andraž, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, TOMAŠIČ, Tihomir. Efflux pump inhibitors of clinically relevant multidrug resistant bacteria. Medicinal research reviews, ISSN 1098-1128, 2019, vol. 39, iss. 6, str. 2460-2504, ilustr. https://onlinelibrary.wiley.com/doi/full/10.1002/med.21591, doi: 10.1002/med.21591. [COBISS.SI-ID 4706929]
• GJORGJIEVA, Marina, TOMAŠIČ, Tihomir, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija. Benzothiazole-based compounds in antibacterial drug discovery : hopes and challenges for a precision medicine. Current medicinal chemistry, ISSN 0929-8673, 2018, vol. 25, iss. 38, str. 5218-5236, ilustr. http://www.eurekaselect.com/156268/article, doi: 10.2174/0929867324666171009103327. [COBISS.SI-ID 4427121]
• GJORGJIEVA, Marina, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Antibacterial and antibiofilm potentials of marine pyrrole-2-aminoimidazole alkaloids and their synthetic analogs. Mini reviews in medicinal chemistry, ISSN 1389-5575, 2018, vol. 18, iss. 19, str. 1640-1658, ilustr. http://www.eurekaselect.com/141805, doi: 10.2174/1389557516666160505120157. [COBISS.SI-ID 4235633]
• GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija. Bisphenol A and its analogs : do their metabolites have endocrine activity?. Environmental toxicology and pharmacology, ISSN 1382-6689. [Print ed.], Oct. 2016, vol. 47, str. 182-199, ilustr. http://www.sciencedirect.com/science/article/pii/S1382668916302447, doi: 10.1016/j.etap.2016.09.014. [COBISS.SI-ID 4184177]
• TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija. Prospects for developing new antibacterials targeting bacterial type IIa topoisomerases. Current topics in medicinal chemistry, ISSN 1568-0266, 2014, vol. 14, no. 1, str. 130-151. http://eurekaselect.com/117940/article, doi: 10.2174/1568026613666131113153251. [COBISS.SI-ID 3579761]

MEDICINAL CHEMISTRY

Design and synthesis of DNA Gyrase B inhibitors

DNA gyrase and topoisomerase IV catalyze changes in DNA topology by breaking and rejoining double stranded DNA. In particular, DNA gyrase introduces negative supercoils in DNA in front of the replication fork, while topoisomerase IV is important for decatenation during DNA replication. Thus, both enzymes are involved in very important processes during DNA replication and are essential for cell viability. Type II topoisomerase is also found in eukaryotic cells, but unlike the prokaryotic enzymes, eukaryotic topoisomerase II is homodimeric. This difference in structure makes selective targeting of prokaryotic topoisomerase II possible. The similarities in the structure of DNA gyrase and topoisomerase IV offer an exceptional opportunity for the dual targeting of these enzymes by new antibacterial compounds, thereby reducing the probability of bacteria to develop target-based resistance against them. Thus, the selectivity of targeting prokaryotic topoisomerase II, the potential of dual targeting, and the well-known structure of these enzymes make both DNA gyrase and topoisomerase IV attractive targets in the challenging search for new antibacterial compounds.

GJORGJIEVA, Marina, TOMAŠIČ, Tihomir, BARANČOKOVA, Michaela, KATSAMAKAS, Sotirios, ILAŠ, Janez, TAMMELA, Päivi, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors. Journal of medicinal chemistry, 2016, 59, 8941-8954.
TOMAŠIČ, Tihomir, KATSAMAKAS, Sotirios, HODNIK, Žiga, ILAŠ, Janez, BRVAR, Matjaž, ŠOLMAJER, Tomaž, MONTALVÃO, Sofia, TAMMELA, Päivi, BANJANAC, Mihailo, ERGOVIĆ, Gabrijela, ANDERLUH, Marko, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Discovery of 4,5,6,7-tetrahydrobenzo[1, 2-d]thiazoles as novel DNA gyrase inhibitors targeting the ATP-binding site. Journal of medicinal chemistry, 2015, 58, 5501-5521.
ZIDAR, Nace, MACUT, Helena, TOMAŠIČ, Tihomir, BRVAR, Matjaž, MONTALVÃO, Sofia, TAMMELA, Päivi, ŠOLMAJER, Tomaž, PETERLIN-MAŠIČ, Lucija, ILAŠ, Janez, KIKELJ, Danijel. N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATP competitive DNA gyrase B inhibitors : design, synthesis, and evaluation. Journal of medicinal chemistry, 2015, 58, 6179-6194.
TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija. Prospects for developing new antibacterials targeting bacterial type IIa topoisomerases. Current topics in medicinal chemistry, 2014, 14, 130-151.

Design and synthesis of voltage-gated potassium and sodium channels

The abnormally increased activity of sodium channels leads to over-excitation of specific groups of cells which can cause different neurodegenerative diseases, chronic pain, epilepsy, arrhythmias and spasticity. A number of preclinical studies have implicated Na_V1.3, Na_V1.7, Na_V1.8 and Na_V1.9 in nociceptive processing and mutations in their genes were linked to spontaneous chronic pain. Mutations of Na_V1.4 that result in hyperactive skeletal sodium channels have been shown to cause myotonia or flaccid paralysis, whereas mutations of Na_V1.5 have profound effects on cardiac function, leading to a range of cardiac abnormalities. Owing to the extremely broad therapeutic potential of VGSC modulators, and to the recently disclosed first X-ray crystal structures of bacterial Na_V channels, discovery of VGSC modulators has become attractive topics in medicinal chemistry. Although there are several drugs acting at Na_V channels, e.g. local anesthetics (lidocaine, procaine), antiarrhythmics (lidocaine, tocainide, mexiletine) and antiepileptics (phenytoin, carbamazepine, lamotrigine), a more rational approach is required to exploit the full therapeutic potential of these drug targets. Current drugs acting on Na_V channels have low potency and are relatively non-selective, therefore there is a need for the development of isoform-selective modulators which offers the promise of significant advantage over current therapeutic agents.

K_v1.3 channels are members of the voltage-gated potassium channel family. The highest expression of K_v1.3 channels is found in T and B lymphocytes and in macrophages. K_v1.3 channels have important roles in the modulation of lymphocyte differentiation, proliferation, migration and apoptosis. Altered expression of K_v1.3 channels has been implicated in several types of tumours and cancers, including solid tumours and lymphomas. It has been demonstrated that selective K_v1.3 channel blockers, such as the scorpion peptide margatoxin, can have marked antiproliferative effects. Recently, small-molecule K_v1.3 blockers have been developed, such as Psora-4 and PAP-1 which are strong inducers of apoptosis in tumour cells. The aim is to develop new selective small-molecule modulators of K_v1.3 based on novel scaffolds, using drug-design methods with the aid of new homology models of human K_v1.3 channels.

ZIDAR, Nace, JAKOPIN, Žiga, MADGE, David J., CHAN, Fiona, TYTGAT, Jan, PEIGNEUR, Steve, SOLLNER DOLENC, Marija, TOMAŠIČ, Tihomir, ILAŠ, Janez, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2- aminoimidazoles as voltage-gated sodium channel modulators. European Journal of Medicinal Chemistry, 2014, 74, 23-30.
HODNIK, Žiga, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, CHAN, Fiona, KIRBY, Robert W., MADGE, David J., KIKELJ, Danijel. Novel state-dependent voltage-gated sodium channel modulators, based on marinealkaloids from Agelas sponges. European Journal of Medicinal Chemistry, 2013, 70, 154-164.

Design and synthesis of Pregnane X receptor (PXR) modulators:

Pregnane X receptors (PXRs) belong to the nuclear receptor superfamily and orchestrate expression of a varied family of genes that are involved in uptake, metabolism and disposal of a number of endobiotics and xenobiotics. Additionally, human PXR triggers the stimulation of phase III efflux transporters of the ABC (i.e., ATP-binding cassette) superfamily, such as P-glycoprotein (Pgp), breast cancer resistance protein (BCRP), and multidrug resistance (MDR) protein (MRP). Its ability to initiate metabolism and efflux of various molecules, and its overexpression in breast, prostate, colon, ovarian, osteosarcoma, and endometrial cancers, makes PXR a promising target for fighting MDR in cancer treatments. For example, the PXR antagonist sulphoraphane increases the chemosensitivity of colorectal cancer cells to irinotecan. This opens the way for the use of PXR antagonists to overcome MDR in cancer chemotherapies.

HODNIK, Žiga, TOMAŠIČ, Tihomir, SMODIŠ, Domen, D'AMORE, Claudio, PETERLIN-MAŠIČ, Lucija, FIORUCCI, Stefano, KIKELJ, Danijel. Diethylstilbestrol-scaffold-based pregnane X receptor modulators. European Journal of Medicinal Chemistry, 2015,103, 551-562.
HODNIK, Žiga, PETERLIN-MAŠIČ, Lucija, TOMAŠIČ, Tihomir, SMODIŠ, Domen, D'AMORE, Claudio, FIORUCCI, Stefano, KIKELJ, Danijel. Bazedoxifene scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists. Journal of medicinal chemistry, 2014, 57, 4819-4833.

Design, synthesis and evaluation of different antiparasitic, antibiofilm and antibacterial compounds (Mur ligase inhibitors)

BENÍTEZ, Diego, MEDEIROS, Andrea, PANOZZO-ZENERE, Esteban A., PROUSIS, Kyriakos C., ROUSSAKI, Marina, CALOGEROPOULOU, Theodora, DETSI, Anastasia, JAEGER, Timo, ŠARALUSKAS, Jonas, PETERLIN-MAŠIČ, Lucija, KUNICK, Conrad, LABADIE, Guillermo R., FLOHÉ, Leopold, COMINI, Marcelo A. Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids. PLoS neglected tropical diseases, 2016, 10, 1-25.
HODNIK, Žiga, ŁOŚ, Joanna M., ŽULA, Aleš, ZIDAR, Nace, JAKOPIN, Žiga, ŁOŚ, Marcin, SOLLNER DOLENC, Marija, ILAŠ, Janez, WĘGRZYN, Grzegorz, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2530-2534.
GJORGJIEVA, Marina, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Antibacterial and antibiofilm potentials of marine pyrrole-2-aminoimidazole alkaloids and their synthetic analogs. Mini reviews in medicinal chemistry, 2016, 16.
ZIDAR, Nace, MONTALVÃO, Sofia, HODNIK, Žiga, NAWROT, Dorota A., ŽULA, Aleš, ILAŠ, Janez, KIKELJ, Danijel, TAMMELA, Päivi, PETERLIN-MAŠIČ, Lucija. Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues. Marine drugs, 2014, 12, 940-963.
TOMAŠIČ, Tihomir, ŠINK, Roman, ZIDAR, Nace, FIC, Anja, CONTRERAS-MARTEL, Carlos, DESSEN, Andréa, PATIN, Delphine, BLANOT, Didier, MÜLLER-PREMRU, Manica, GOBEC, Stanislav, ZEGA, Anamarija, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija. Dual inhibitor of MurD and MurE ligases from Escherichia coli and Staphylococcus aureus. ACS Medicinal Chemistry Letters, 2012, 3, 626-630.
BARRETEAU, Hélène, SOSIČ, Izidor, TURK, Samo, HUMLJAN, Jan, TOMAŠIČ, Tihomir, ZIDAR, Nace, HERVÉ, Mireille, BONIFACE, Audrey, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel, MENGIN-LECREULX, Dominique, GOBEC, Stanislav, BLANOT, Didier. MurD enzymes from different bacteria: evaluation of inhibitors. Biochemical pharmacology, 2012, 85, 625-632.
TOMAŠIČ, Tihomir, KOVAČ, Andreja, KLEBE, Gerhard, BLANOT, Didier, GOBEC, Stanislav, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija. Virtual screening for potential inhibitors of bacterial MurC and MurD ligases. Journal of molecular modeling, 2012, 18, 1063-1072.
TOMAŠIČ, Tihomir, KOVAČ, Andreja, SIMČIČ, Mihael, BLANOT, Didier, GOLIČ GRDADOLNIK, Simona, GOBEC, Stanislav, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija. Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting d-Glu- and diphosphate-binding site. European Journal of Medicinal Chemistry, 2011, 46, 3964-3975.
ZIDAR, Nace, TOMAŠIČ, Tihomir, ŠINK, Roman, KOVAČ, Andreja, PATIN, Delphine, BLANOT, Didier, CONTRERAS-MARTEL, Carlos, DESSEN, Andréa, MÜLLER-PREMRU, Manica, ZEGA, Anamarija, GOBEC, Stanislav, PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation. European Journal of Medicinal Chemistry,  2011, 46, 5512-5523.
TOMAŠIČ, Tihomir, ZIDAR, Nace, ŠINK, Roman, KOVAČ, Andreja, BLANOT, Didier, CONTRERAS-MARTEL, Carlos, DESSEN, Andréa, MÜLLER-PREMRU, Manica, ZEGA, Anamarija, GOBEC, Stanislav, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija. Structure-based design of a new series of D-Glutamic acid-based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). Journal of medicinal chemistry,  2011, 54, 4600-4610.
ŠKEDELJ, Veronika, TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija, ZEGA, Anamarija. ATP-binding site of bacterial enzymes as a target for antibacterial drug design. Journal of medicinal chemistry, 2011, 54, 915-929.

New anticancer compounds:

NABERGOJ, Dominik, VRBEK, Sanja, ZIDAR, Nace, TOMAŠIČ, Tihomir, KIKELJ, Danijel, PETERLIN-MAŠIČ, Lucija, MULLER, Christian D. Synthetic analogues of marine alkaloid clathrodin differently induce phosphatidylserine exposure in monocytic cancer cell then in cancer stem cell lines. MedChemComm, 2016, 7, 1546-1554.
TOMAŠIČ, Tihomir, NABERGOJ, Dominik, VRBEK, Sanja, ZIDAR, Nace, JAKOPIN, Žiga, ŽULA, Aleš, HODNIK, Žiga, JUKIČ, Marko, ANDERLUH, Marko, ILAŠ, Janez, SOLLNER DOLENC, Marija, PELUSO, Jean, UBEAUD-SÉQUIER, Geneviève, MULLER, Christian D., PETERLIN-MAŠIČ, Lucija, KIKELJ, Danijel. Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells. MedChemComm, 2015, 6, 105-110.

Critical review about rhodanines in drug discovery

TOMAŠIČ, Tihomir, PETERLIN-MAŠIČ, Lucija. Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation. Expert opinion on drug discovery, 2012, 7, 549-560.

TOXICOLOGY

Mechanisms of toxicity of endocrine disrupting chemicals (BPA analogs, novel brominated flame retardants)

In our laboratory we evaluate the influences of different metabolic reactions on the endocrine activity of endocrine disrupting chemicals such as BPA analogs and novel brominated flame retardants. Metabolism can change or even abolish the endocrine activity of a compound. In contrast, in some cases, metabolism enhances endocrine activity, as was previously described for the oxidative metabolites of BPA and bisphenol B (2,2-bis(4-hydroxyphenyl)butane). Therefore, we study in-vitro metabolism of compounds by human liver microsomes (HLM), human intestine microsomes (HIM), and  recombinant human CYP450 enzymes, such as CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2E1, CYP3A4 to determine whether or not they generate oxidative metabolites in-vitro and to find out which is the major CYP450 enzyme responsible for these reactions. We determine the endocrine activities of compounds on estrogen, androgen, thyroid and glucocorticoid receptors using different cell lines. Since many of metabolites such as glucuronides are not commercially available, we can also perform enzyme-assisted synthesis of glucuronides, using HLMs as the enzyme source.

GRAMEC, Darja, SCHMIDT, Jan, FIC, Anja, KLOPČIČ, Ivana, TRONTELJ, Jurij, SOLLNER DOLENC, Marija, FINEL, Moshe, PETERLIN-MAŠIČ, Lucija. Influence of metabolism on endocrine activities of bisphenol S. Chemosphere, 2016, 157, 152-159.
KLOPČIČ, Ivana, GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija, SOLLNER DOLENC, Marija. Comparison of in vitro hormone activities of novel flame retardants TBB, TBPH and their metabolites TBBA and TBMEPH using reporter gene assays. Chemosphere, 2016, 160, 244-251.
GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija. Bisphenol A and its analogs: do their metabolites have endocrine activity?. Environmental toxicology and pharmacology, 2016, 47, 182-199.
GRAMEC, Darja, TOMAŠIČ, Tihomir, CARINO, Adriana, DISTRUTTI, Eleonora, FIORUCCI, Stefano, PETERLIN-MAŠIČ, Lucija. New brominated flame retardants and their metabolites as activators of the pregnane X receptor. Toxicology letters, 2016, 259, 116-123.
FIC, Anja, JURKOVIĆ MLAKAR, Simona, JUVAN, Peter, MLAKAR, Vid, MARC, Janja, SOLLNER DOLENC, Marija, BROBERK, Karin, PETERLIN-MAŠIČ, Lucija. Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicology in vitro, 2015, 29, 1060-1069.
GRAMEC, Darja, TROBERG, Johanna, JAVDAS, Jason, PETERLIN-MAŠIČ, Lucija, FINEL, Moshe. Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10. Xenobiotica, 2015, 45, 511-519.
FIC, Anja, ŽEGURA, Bojana, GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija. Estrogenic and androgenic activities of TBBA and TBMEPH, metabolites of novel brominated flame retardants, and selected bisphenols, using the XenoScreen XL YES/YAS assay. Chemosphere, 2014, 112, 362-369.
FIC, Anja, ŽEGURA, Bojana, SOLLNER DOLENC, Marija, FILIPIČ, Metka, PETERLIN-MAŠIČ, Lucija. Mutagenicity and DNA damage of bisphenol A and its structural analogs = Mutagenost in poškodbe DNA povzročene z bisfenolom A in njegovimi strukturnimi analogi. Arhiv za higijenu rada i toksikologiju, 2013, 64, 189-200.
SCHMIDT, Jan, PETERLIN-MAŠIČ, Lucija. Organic synthetic environmental endocrine disruptors: structural classes and metabolic fate. Acta chimica slovenica, 2012, 59, 722-738.

Detection and evaluation of reactive metabolites:

For the detection of reactive metabolites of different xenobiotics, we study compounds in human liver microsomes and with different CYP450 isozymes using reduced glutathione (GSH) as a trapping agent. GSH conjugates are detected by LC–MS/MS using three modes of scanning: a full scan, multiple reaction monitoring (MRM) and precursor ion scan (PIS) of m/z = 272 with negative ionization. To investigate P450 oxidative reactions, incubations were treated with NADPH as a cofactor and GSH as a trapping agent. GSH usage was also preferred due to the fact that it does not inhibit P450s. This configuration represents a classical testing system that is widely employed in detection of reactive metabolites.

GRAMEC, Darja, PETERLIN-MAŠIČ, Lucija, SOLLNER DOLENC, Marija. Bioactivation potential of thiophene-containing drugs. Chemical research in toxicology, 2014, 27, 1344-1358.
SCHMIDT, Jan, KOTNIK, Petra, TRONTELJ, Jurij, KNEZ, Željko, PETERLIN-MAŠIČ, Lucija. Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes. Toxicology in vitro,2013, 27,  1267-1276.
TRDAN LUŠIN, Tina, TOMAŠIČ, Tihomir, TRONTELJ, Jurij, MRHAR, Aleš, PETERLIN-MAŠIČ, Lucija. In vitro bioactivation of bazedoxifene and 2-(4-hydroxyphenyl)-3-methyl-1Hindol- 5-ol in human liver microsomes. Chemico-biological interactions,  2012, 1, 8-15.
PETERLIN-MAŠIČ, Lucija. Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship. Current drug metabolism, 2011, 12,  35-50.

Drugs overdoses and substance abuse:

BRVAR, Miran, KOŽELJ, Gordana, PETERLIN-MAŠIČ, Lucija. Hypoglycemia in venlafaxine overdose : a hypothesis of increased glucose uptake. European Journal of Clinical Pharmacology, 2015, 71, 261-262.
OSTROVRŠNIK, Jaka, CVIRN, Anina, PETERLIN-MAŠIČ, Lucija. Amfetamin in metamfetamin: mehanizem delovanja, učinki, zastrupitev in diagnostika = Amphetamine and methamphetamine: mechanism of action, effects, poisoning and diagnostics. Medicinski razgledi, 2011, 50, 17-32.

Management functions and Membership of International Societies: 2004- 2014 President of the Section for Medicinal Chemistry at the Slovenian Pharmaceutical Society; Member of European Federation of Medicinal Chemistry (EFMC); Member of Slovenian Toxicology Society; Member of Slovenian Pharmaceutical Society ; Member of EUROTOX (Federation of European Toxicologists and  European Societies of Toxicology); 2013- Treasurer at the Slovenian Toxicology Society.

Committees: 2010- Committee of Medicinal Products for Veterinary Use; 2009-2013 Committee for research equipment at the Faculty of Pharmacy.

Editorial board member: 2010- 2014 Editorial board of MedChemWatch.   

Reviewer in international journals: European journal of Medicinal Chemistry, Journal of Medicinal Chemistry, Chemosphere, Journal of Medicinal Chemistry.

Organization of International Meetings: Head of the Organizing Committee of the 5^th JMMC (Joint Meeting on Medicinal Chemistry), Portorož 2007, Slovenia; Head of the Organizing Committee of the 4^th BBBB (New Trends in Drug Discovery, Delivery Systems and Laboratory Diagnostics), Bled 2011, Slovenia; Head of the Organizing Committee of the 2^nd Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Ljubljana, September 2012.

Member of the International Scientific Committee of ISMC (international Symposiums on Medicinal Chemistry) symposiums: ISMC Berlin, 2012 and ISMC Lisbon, 2014.