| RAZISKOVALNA PODROČJA:
- Sinteza zdravilnih učinkovin:
Totalna sinteza zdravilnih učinkovin, asimetrična sinteza zdravilnih učinkovin, kataliza v sintezi zdravilnih učinkovin (organokataliza, organokovinska kataliza in encimatska kataliza), heterociklična kemija
- Stabilnost zdravilnih učinkovin:
Napovedovanje in študij razkroja zdravilnih učinkovin
- Analitika zdravilnih učinkovin:
metode tekočinske kromatografije in NMR za vrednotenje kakovosti zdravilnih učinkovin
- Polimorfizem zdravilnih učinkovin:
sinteza in karakterizacija novih trdnih oblik zdravilnih učinkovin (polimorfi, solvati ko-kristali)
BIBLIOGRAFIJA:
objavljenih 63 člankov v SCI revijah (od tega prvi oz. vodilni avtor pri 58 člankih). Reprezentativne objave:
Lactone Pathway to Statins Utilizing the Wittig Reaction. The Synthesis of Rosuvastatin, J. Org. Chem., 2010, 75, 6681–6684. http://pubs.acs.org/doi/10.1021/jo101050z
Iridium-Catalyzed Chemoselective and Enantioselective Hydrogenation of (1-Chloro-1-Alkenyl) Boronic Esters, Angew. Chem. Int. Ed., 2012, 51, 1014–1018. http://onlinelibrary.wiley.com/doi/10.1002/anie.201106262/full
Application of Flow Photochemical Bromination in the Synthesis of a 5-Bromomethylpyrimidine Precursor of Rosuvastatin: Improvement of Productivity and Product Purity, Org. Process Res. Dev., 2013, 17, 145–151. http://pubs.acs.org/doi/10.1021/op300248y
Cobalt-Catalyzed Cross-Coupling of Grignards with Allylic and Vinylic Bromides: Use of Sarcosine as a Natural Ligand, J. Org. Chem., 2015, 80, 7803–7809. http://pubs.acs.org/doi/10.1021/acs.joc.5b01156
Development of Concise Two-step Catalytic Approach Towards Lasofoxifene Precursor Nafoxidine, Bioorg. Med. Chem., 2018, 26, 2691–2697. https://www.sciencedirect.com/science/article/pii/S0968089618303353
Understanding and Kinetic Modeling of Complex Degradation Pathways in the Solid Dosage Form: The Case of Saxagliptin, Pharmaceutics 2019, 11, 452. https://www.mdpi.com/1999-4923/11/9/452
Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates, Pharmaceutics 2020, 12, 342. https://www.mdpi.com/1999-4923/12/4/342
Synthetic Approaches to Contemporary Drugs that Contain the Cyclopropyl Moiety, Synthesis 2020, 52, 1315–1345, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1690058
Concise Six-Step Asymmetric Approach to Ramelteon from an Acetophenone Derivative Using Ir, Rh, Cu, and Ni Catalysis. J. Org. Chem. 2022, 87, 4, 2129–2135. https://doi.org/10.1021/acs.joc.1c01614
Primary trifluoroborate-iminiums enable facile access to chiral α-aminoboronic acids via Ru-catalyzed asymmetric hydrogenation and simple hydrolysis of the trifluoroborate moiety. Chem. Sci. 2022,13, 2946–2953. https://doi.org/10.1039/D1SC07065G
>80 podeljenih mednarodnih patentov (EU, US, JP, CN, CA) s popolnim preizkušanjem patentne prijave
Urednik in soavtor monografije z naslovom »Synthesis of Heterocycles in Contemporary Medicinal Chemistry« v seriji Topics in Heterocyclic Chemistry pri založbi Springer (http://www.springer.com/gp/book/9783319399157)
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| 2010 – sedanjost: recenzent za znanstvene publikacije pri založbah:
American Chemical Society Publications, ZDA (revije ACS Omega, Organic Process Research & Development, Industrial & Engineering Chemistry Research, The Journal of Organic Chemistry, Organometallics, Organic Letters ter The Journal of the American Chemical Society)
Wiley-VCH, Nemčija (revije Chirality, Applied Organometallic Chemistry, European Journal of Organic Chemistry, Chemistry - A European Journal, ChemCatChem, ChemSusChem ter Advanced Synthesis & Catalysis)
Thieme, Nemčija (reviji Synlett in Synthesis)
Royal Society of Chemistry, Anglija (revija Organic Chemistry Frontiers)
ter nekatere ostale založbe/revije.
2021 – sedanjost: član Glavnega odbora Slovenskega kemijskega društva
2015 – sedanjost: član ekspertne skupine 10D pri European Directorate for the Quality of Medicines & HealthCare (EDQM, Strasbourg, Francija)
2009 – 2017: član »Sandoz Scientific Core Team« in »Sandoz Development, Science and Systems Committee«
2010 – 2017: vodja znanstvenega odbora in član organizacijskega odbora »Regijskega BioCampa Lek«
2015 – 2017: član delovne skupine za pripravo poklicnih standardov s področja kemije pri Centru RS za poklicno izobraževanje
2016 – 2018: podpredsednik sveta Ustanove Slovenska znanstvena fundacija
2018 – 2019: predsednik sveta Ustanove Slovenska znanstvena fundacija in član uprave Ustanove Slovenska znanstvena fundacija
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