National projects
Range:
Role of APOBEC proteins in the oncogenesis of HPV viruses
Human papillomaviruses (HPV) are one of the most prevalent sensually transmitted pathogens, responsible for more than 5 % of all cancers in humans, including cervical cancer and HPV-associated head-and-neck cancer. APOBEC3 (A3) proteins are cytidine deaminases that are capable of DNA and RNA editing. DNA-editing activity represent a key part of the innate immune response to viral infections. Howev...
Structural insight into iodine metabolism
Iodine is the heaviest essential trace element required by the higher living organisms. It is incorporated in T3/T4 hormones responsible for regulation of basal metabolism of almost any cell. T3 and T4 hormones are produced in the thyroid gland. The thyroid hormone metabolism involves selenium containing deiodinases and additional selenoperoxidases and thioredoxin p...
Selective mechanical removal of bacterial biofilms by conjugated magnetic nanoparticles
Biofilms are microbial communities protected by a self-synthesized layer of extracellular polymeric substance that form on surfaces. Biofilms protect the bacteria from the host immune system and enable them to persist in adverse environmental conditions. They are an important clinical and public health problem, as up to 80% of all bacterial infections in humans ar...
01. October 2022 - 30. September 2025 | 1-09 Natural sciences and Mathematics - Pharmacy
The Role and Potential Application of Immunomodulatory Mesenchymal Stem Cells in COVID- 19 Disease
The declared pandemic caused by new SARS-CoV-2 virus in 2020, did not catch the research organizations and pharmaceutical companies completely unprepared. Many scientific groups have already carried out research that was indirectly addressing the challenges facing the international health systems of today. In Slovenia, high level of scientific and professional healt...
Recombinant probiotics as bio-alternative antimicrobial approach against Clostridioides difficile
Clostridioides difficile infections represent a growing and serious health threat, particularly for the elderly and immune-compromised patients in the hospital setting. C. difficile causes a spectrum of pathological conditions ranging from mild self-limiting diarrhea, to serious diarrhea, pseudomembraneous colitis and potentially lethal fulminant colitis. C. diffici...
Autologous immunohybridomas and advanced treatment of stage II and III triple-negative breast cancer
Breast cancer (BC) is a significant and common disease with a negative effect prevalently on women health, and the second most deadly type of cancer in females. BC is a highly heterogeneous disease due to its diverse morphological features, variable clinical outcomes and responses to currently available therapeutic options. Due to its high degree of heterogene...
Development of new inhibitors of bacterial topoisomerases to overcome antimicrobial resistance
In recent years, we observed an alarming increase in life-threatening infections due to resistant Gram-positive and Gram-negative pathogens and mycobacteria. Resistance has evolved to every single antibacterial drug that has been introduced to the clinic, which strongly limits our treatment options. New antibacterials specifically aimed at resistant infe...