National projects

Despite recent advances in biophysical techniques and computational approaches for the investigation of biomolecular systems, the characterization of the dynamic equilibria of protein states remains a demanding challenge due to the elusive nature of the dynamic processes that regulate these equilibria. In particular, the sparsely populated, transient states are diff...

Cannabidiol (CBD) belongs to naturally occurring cannabinoids, the unique group of bioactive constituents of hemp. CBD exerts a variety of pharmacological effects but does not have the psychotropic   properties, which are characteristic for THC. In addition to certain clinical applications, nowadays CBD is the focus of mass marketing campaigns and the subj...

Age-related macular degeneration (AMD) is the most common form of visual impairment in the world, affecting more than 67 million people in the EU alone. Early stages are often asymptomatic and there is no cure or treatment to reverse the course of the disease. Supplementation with two natural xanthophylls, lutein and zeaxanthin, is currently the only effective measu...

Despite advances over the past years the treatment of breast cancer is still facing many challenges, among them overcoming cancer recurrence and avoiding therapy resistance are the main goals in the aim to improve patients’ status. Failure   in antitumor therapy has been, among the phenotypically and functionally heterogenous population of cells with...

The mechanisms and pathogenesis of many neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease are not completely understood. However, it is hypothesized that clearance of amyloid beta (Ab) aggregates in AD-patient can result in cognitive improvement and reverse the progression of disease. The Ab aggregates should be disrupted into insoluble...

The project addresses establishment of electrospinning needle-free technology of biocompatible bimodal polyamide 6 that will be used for manufacturing containers for Solid State Drug Delivery approach. This approach utilizes polymeric electrospun nanofibrous materials as a shell material for drug carrier containers for targeted chemotherapy of localized tumors and p...

In nature, the extracellular matrix, which encloses bacterial cells, has a vital role for normal cell functioning. Such confinement serves as protection against predators and antimicrobial agents, allows the establishment of high cell densities and co-aggregation of different types of cells and provides a matrix, where different bioactive molecules can concentrate. ...

Scientific background and problem introduction Urinary bladder cancer is 6th among all cancers worldwide and 1/3 of urinary bladder cancer emerges as multifocal tumours at different sites of the urothelium, e.g. epithelium which represents effective blood-urine barrier. Treatment usually includes the resection of the tumours during the transurethral resection of the...

It is well known that the microbial biofilms pose a significant risk for human health and economy. The increased resistance of microbes in biofilms against antimicrobial agents presents a major challenge for microbial biotechnology. The current research identifies the extracellular matrix that can vary in its exopolymeric (EPS) composition significantly even in the ...

Alzheimer disease is becoming one of the leading problems of modern medicine, affecting patients, their families and draining national health care budgets worldwide. According to predictions, in the near future, Alzheimer disease shall be inevitable for more than one third of the population aged over 65 years. Development of a reliable diagnostic tool for early diag...