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National projects

Development of new carbamate-based imaging probes for cholinesterases

Cholinesterases (ChEs) are polymorphic serine hydrolases that catalyse the hydrolysis of neurotransmitter acetylcholine (ACh) and other esters. Two ChEs are found in vertebrates: acetylcholinesterase (AChE) and butyrycholinesterase (BChE). Both enzymes are involved not only in physiological processes but also in several pathophysiological processes (e.g.  Alzhe...

01. April 2020 - 31. March 2021 | 1.09 Pharmacy

Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease

Periodontal disease is perhaps the most common human afflictions, and through its local and systemic effects, it can considerably deteriorate the overall quality of person’s life. Periodontal disease is a biofilm-induced chronic inflammation of the periodontium, where two factors are specifically linked with its pathogenesis: (i) a shift in the oral microbiota...

30. June 2018 - 30. June 2021 | 1.09 Pharmacy

Nanotheranostics based on magneto-responsive materials

Various types of cancers represent a great challenge to the health care system nowadays, since 3 million people are diagnosed for cancer annually in Europe. The efficacy of available anticancer medicines and therapeutic approaches is limited and often associated with serious side effects due to unspecific drug distribution in a human body. This problem can be prevented or limited with the incorpor...

31. December 2015 - 30. December 2018 | 1.09 Pharmacy

Optimization of nitroxoline-based inhibitors of cathepsin B as potential drugs for the treatment of cancer

Human cathepsin B is a lysosomal cysteine protease that has many house-keeping functions, such as intracellular proteolysis. It can act as both an endopeptidase and an exopeptidase, a characteristic that is attributed to a 21-amino-acid insertion above the active site. Dysregulation of cathepsin B activity is associated with many pathological states. The most thorou...

31. December 2015 - 30. December 2017 | 1.09 Pharmacy