Research ARRS Projects


sorted by code






Smart probes for ex vivo assay-based early prediction of Alzheimer disease 

1.10.2021 - 30.9.2024 

UL FKKT Janez Košmrlj
UL FFA Stanislav Gobec


A synthetic biofilm-based platform for studying and development of new antibiofilm strategies 

1.10.2021 - 30.9.2024 

UL BF Iztok Dogša
UL FFA Nace Zidar


MTAvsAMR: new MultiTargeting Antibiotics against AntiMicrobial Resistance 

1.10.2021 - 30.9.2024 

Lucija Peterlin Mašič


Development of new inhibitors of bacterial topoisomerases to overcome antimicrobial resistance

1.10.2021 - 30.9.2024 

Nace Zidar


Evaluation of transient protein states

1.10.2022 - 30.9.2025 

KI Simona Golič Grdadolnik
FFA  Stanislav Gobec

J1-4402  Dynamical model of a type II DNA topoisomerase biological nanomachine and design of catalytic inhibitors

1.10.2022 - 30.9.2025 

KI Andrej Perdih
UL FFA Marija Sollner Dolenc 


ProBiS-Fold approach for binding site detection for whole structural human proteome in drug discovery 

1.10.2022 - 30.9.2025 

UP FAMNIT Dušanka Janežič
UL FFA Stanislav Gobec


Development of novel small molecule Toll-like receptors 7 and 8 modulators for cancer immunotherapy

1.10.2022 - 30.9.2025 

Matej Sova
J1-50023 3DfluorCO - Three-dimensional fluorine-based carbonyl bioisosteres: asymmetric synthesis and validation  1.10.2023 - 30.9.2026 Andrej Emanuel Cotman


Development of CDK1-selective degraders for the treatment of T-cell malignancies    1.10.2023 - 30.9.2026  Izidor Sosič 
J1-50038  New Hsp90 Inhibitor-based Therapies for Ewing Sarcoma  1.1.2024 - 31.12.2026 Tihomir Tomašič 


Breaking the Walls: Development of Inhibitors of D,D- and L,D-Transpeptidases   1.10.2023 - 30.9.2026  Stanislav Gobec 


Exploitation of the magneto-mechanical effect in the treatment of neurodegenerative diseases 

1.10.2021 - 30.9.2024 

IJS Slavko Kralj
UL FFA Petra Kocbek


Removal of selected antimicrobials by plasma-cavitation technology from water matrices of varying complexities (Causma)

1.10.2022 - 30.9.2025 

FS Martin Petkovšek            
FFA Jurij Trontelj


Autologous immunohybridomas and advanced treatment of stage II and III triple-negative breast cancer 

1.10.2021 - 30.9.2024 

Matjaž Jeras


Cathepsins B and X in breast cancer stem cells – molecular targets and relevance for antitumor therapy 

1.10.2021 - 30.9.2024 

IJS Ana Mitrović
UL FFA Janko Kos


Bactericidal nanoblades: a proof-of-concept approach for bimodal chemo-mechanical eradication of persistent biofilms 

1.12.2021 - 30.11.2024 

Stane Pajk


Next-generation adjuvants for mucosal vaccines

1.10.2022 - 30.9.2025 

Žiga Jakopin


Mechanisms of response to interleukin 12/23 blockers in ulcerative colitis - toward personalized medicine

1.10.2022 - 30.9.2025 

UKC David Drobne
UL FFA Iztok Grabnar


Muscle cell secretom and bone cells interplay in osteosarcopenia (MiKOSA)

1.10.2022 - 30.9.2025 

Janja Marc

J3-50099 A novel therapeutic strategy for allergic diseases based on epitope-paratope blocking   1.10.2023 - 30.9.2026 UKC Golnik Viktorija Tomič
UL FFA Mojca Lunder 


Matters of the heart: elucidating the cardiotoxic mechanism of proteasome inhibitors  1.10.2023 - 30.9.2026 

Martina Gobec

J3-50123  Bacterial Biofilm Formation Inhibitors: A Novel Approach to Combat Antimicrobial Resistance  1. 10. 2023 - 30. 09. 2026  Martina Hrast Rambaher 


Development of biologically active and chemically stable xanthophylls based on a sustainable esterification of xanthophylls from renewable natural resources 

1.10.2021 - 30.9.2024 

KI Alen Albreht
UL FFA Ilija German Ilić


Recombinant probiotics as bio-alternative antimicrobial approach against Clostridioides difficile 

1.10.2021 - 30.9.2024 

Borut Štrukelj


New biofertilization approach based on the microbial multispecies biocatalytic aggregates

1.10.2022 - 30.9.2025 

IJS Tomaž Rijavec
UL FFA Špela Zupančič


Valorization of Himalayan balsam (Impatiens glandulifera Royle) waste to design bioactive extracts with a potential protective activity on the human vascular system  1.10.2023 - 30.9.2026 KI Alen Albreht 
UL FFA Lovro Žiberna 


Nanofibers for codelivery of selected microbiota cocktails and antimicrobials for local treatment of vaginal infections

1.10.2022 - 30.9.2025 

Špela Zupančič


Selective mechanical removal of bacterial biofilms by conjugated magnetic nanoparticles

1.10.2022 - 30.9.2025 

IJS Aleš Berlec
UL FFA Marko Anderluh


MitoCan - Preclinical development of new Mitochondrial ion channel inhibitors for Cancer therapy

1.10.2022 - 30.9.2025 

Lucija Peterlin Mašič


Development of highly concentrated protein formulations and evaluation of absorption kinetics after subcutaneous administration 

1.10.2021 - 30.9.2024 

Iztok Grabnar


Quantitative light scattering spectroscopy as a process analytical technology in pharmaceutical manufacturing

1.10.2022 - 30.9.2025 

FKKT Franjo Pernuš
UL FFA Rok Dreu


The Role and Potential Application of Immunomodulatory Mesenchymal Stem Cells in COVID- 19 Disease 

1.10.2021 - 30.9.2024 

Janja Zupan


Safety evaluation of cannabidiols and implications for public health and consumers behaviour 

1.10.2021 - 30.9.2024 

NIB Metka Filipič
UL FFA Jurij Trontelj

L4-4564  Biotechnological potential of selected microorganisms from Sečovlje Saltpans for application in cosmetics products  1.10.2022 - 30.9.2025  NIB Ana Rotter
UL FFA Alenka Zvonar Pobirk
L7-50044   Efficacy and safety of dietary supplementation in targeting sleep quality: an evidence-based approach for supporting informed choices  1.10.2023 - 30.9.2026  Igor Pravst
UL FFA Mitja Kos 
A covalent approach against antibiotic resistance  1.1.2021 - 31.12.2023  Stanislav Gobec 
N1-0172  Photochemistry toolbox for discovery of advanced ATP-competitive chemical probes with Topoisomerase IIalpha inhibitory activity  1.1.2021 - 31.12.2023  Janez Ilaš
N1-0277 Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease  1.1.2023 - 31.12.2025  Stanislav Gobec 
N1-0331  A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven diseases  1.1.2024 - 31.12.2027  Izidor Sosič 
N1-0363  Bisphenol A substitutes: health risks to the endocrine and cardiovascular systems (Acronim: BPAsubRisk)  1.3.2024 - 28.2.2027  Marija Sollner Dolenc  
Z1-4405  Development of new antibiotics simultaneously targeting beta-lactamases and penicillin-binding proteins   1.10.2022 - 30.9.2024   Alen Krajnc



sorted by code





J1-1709   Structural insight into the mechanism of Clostridium difficile surface formation   1.7.2019 - 30.6.2023  IJS dr. Dušan Turk 
FFA dr. Janez Mravljak


Protein interaction atlas for prediction of genetic variations involved in drug interactions and disease development

1.7.2019 - 30.6.2022

Dušanka Janežič

Development of novel Hsp90 inhibitors with anticancer activity   1.7.2019 - 30.6.2023 Tihomir Tomašič
J1-2483   Radiopharmaceuticals with antagonistic activity on CCK2R 
 1.9.2020 - 31.8.2023  Marko Anderluh 
J1-2484   Development of antibacterial compounds targeting validated enzymes in peptidoglycan biosynthesis    1.9.2020 - 31.8.2023  Stanislav Gobec 


The kiss of death for key apoptosis players: development of BCL-2 and BAX PROTACs 
 1.9.2020 - 31.8.2023  Izidor Sosič 


Nanotheranostics based on magneto-responsive materials

1.1.2016 - 31.12.2018

Petra Kocbek


Structural insight into iodine metabolism

1.1.2016 - 31.12.2018

FFA Stanislav Gobec


Receptors for toxins of plant pathogens

1.1.2016 - 31.12.2018

KI Gregor Anderluh
FFA Stanislav Gobec


Endocrine disrupting and genotoxic potential of protein kinase inhibitors: relevance for environmental hazard in zdravje ljudi

1.5.2017 - 30.4.2020

NIB Metka Filipič
FFA Marija Sollner Dolenc


Dynamic aspect of ligand-protein binding

1.5.2017 - 30.4.2020

KI Simona Golič Grdadolnik
FFA Stanislav Gobec


Inhibition of Staphylococcus aureus cell wall remodeling

1.5.2017 - 30.4.2020

IJS Dušan Turk
FFA Marko Anderluh


New anticancer leads for emerging cancer target potassium ion channels hEag1 and its validation in lymphoma tumors

1.7.2018 - 30.6.2021

Lucija Peterlin Mašič


Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease

1.7.2018 - 30.6.2022

Julijana Kristl

J3-1745   Elucidating the role of immunoproteasome in platelet-driven immune response   1.7.2019 - 30.6.2023  Martina Gobec 
J3-1749   Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system    1.7.2019 - 30.6.2023  Janja Zupan 


Comprehensive characterization of GWAS hits – pipeline to novel drug targets for anabolic treatment of osteoporosis (GWASforAna)

1.7.2019 - 30.6.2022

Janja Marc

Development of innate immune receptor-targeting chimeras as custom-tailored vaccine adjuvants   1.9.2020 - 31.8.2023   Žiga Jakopin 
J3-2518   Role of APOBEC proteins in the oncogenesis of HPV viruses  1.9.2020 - 31.8.2023   UNG Martina Bergant Marušič
UL FFA Marija Nika Lovšin 
J3-2521   Inflammatory process in interstitial cystitis and evaluation of the influence of cannabinoid receptor agonists in urinary bladder - from cells to patients   1.9.2020 - 31.8.2023   UL MF Peter Veranič
FFA Mojca Kerec Kos 


Identification of new expression regulators of RANKL, a key molecule not only in bone remodelling

1.1.2016 - 31.12.2018

Janja Marc


Tunneling nanotubes for innovative urinary bladder cancer treatments

1.1.2016 - 31.12.2018

MF Mateja Erdani Kreft
Petra Kocbek


New frontiers in folate supplementation in obstetrics and gynaecology (NFFS OB-GYN)

1.5.2017 - 30.4.2020

UKC LJ Ksenija Geršak
FFA Irena Mlinarič-Raščan


Potential of low, sub-therapeutic doses of statins and sartans in primary and secondary cardiovascular disease prevention

1.5.2017 - 30.4.2020

UKC LJ Mirza Šabovič
FFA Janja Marc


Development of NOD2 agonists and dual NOD2/TLR7 agonistic conjugates as novel vaccine adjuvants

1.7.2018 - 30.6.2022

Žiga Jakopin


Inhibition of cathepsin X activity as a novel strategy for the treatment of Parkinson's disease

1.7.2018 - 30.6.2021

Anja Pišlar


Selective extraction of high value molecules from forest products processing residues in the speciality chemicals sector

1.7.2019 - 30.6.2022

InnoRenew Andreja Kutnar
FFA Samo Kreft


Improvement of immunotherapeutic potential of NK cells through modulation of cystatin F

1.7.2019 - 30.6.2022

Janko Kos


Exploitation of a virus-borne small protein to combat antibiotic resistance in Staphylococcus aureus

1.7.2019 - 31.12.2022

UL BF Matej Butala
FFA Stanislav Gobec


Electrostatic immobilisation of bacterial cells and effects on their physiology

1.3.2016 - 28.2.2019

IMMT Aleš Lapanje
FFA Julijana Kristl


Cathepsin X inhibitors impair the resistence of tumor cells to antiprotease therapy

1.5.2017 - 30.4.2020

Janko Kos


Targeting, imaging and treating of colorectal cancer with safe theranostic bacteria

1.7.2018 - 30.6.2021

JS Aleš Berlec
FFA Janko Kos

J7-2603   Efficacy of bacteriophages for treatment of extracellular and intracelular bacterial infections of implantants    1.9.2020 - 31.8.2023  UL FKKT Aleš Podgornik
UL FFA Janja Zupan 


Development of multifunctional compounds for treatment of Alzheimer's disease

1.5.2017 - 30.4.2020

Stanislav Gobec


Elecrospun nanofibrous materials for solid state drug delivery system

1.3.2016 - 28.2.2019

OI Igor Emri
FFA Albin Kristl


Identification of non-peptidic inhibitors of the immunoproteasome using fragment based drug discovery methods

1.11.2017 - 31.10.2020

Stanislav Gobec


Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity

1.1.2019 - 31.12.2022

Lucija Peterlin Mašič


NOBIL - Novel Biomarkers in Leukemia

1.5.2018 - 30.4.2020

Irena Mlinarič Raščan


Development of new carbamate-based imaging probes for cholinesterases

1.4.2019 - 31.3.2021

Stanislav Gobec


Selection and preparation of a dossier potentially neurotoxic chemical using in silico methods for the purpose of implementing the European chemical legislation REACH

1.11.2019 - 31.10.2020

KI Marjan Vračko - Grobelšek
FFA Marija Sollner Dolenc


New psychoactive substances monitoring system in Slovenia (acronym SONDA)

1.10.2016 - 30.9.2018

UKC LJ Miran Brvar
FFA Lucija Peterlin Mašič


The use of hop products for organic control of varroa (Varroa destructor)

1.10.2016 - 30.9.2019

IHPS Košir Iztok Jože
FFA Stanko Srčič


DNA vaccine and peptide inhibitors against SARS-CoV-2

1.10.2020 - 30.9.2022

KI Roman Jerala
FFA Borut Štrukelj


Targeted covalent inhibitors: inhibiting monoamine oxidase through non-catalytic amino-acid residues

1.7.2019 - 30.6.2021

Damijan Knez


Modular asymmetric total synthesis of bioactive multi-chiral natural products

1.9.2020 - 31.8.2022

Andrej Emanuel Cotman


Optimization of nitroxoline-based inhibitors of cathepsin B as potential drugs for the treatment of cancer

1.1.2016 - 31.12.2017

Izidor Sosič


Discovery of new inhibitors of bacterial peptidoglycan biosynthesis enzymes MurA and MurB

1.5.2017 - 30.4.2019

Marko Jukič


Butyrylcholinesterase inhibitors for alleviating symptoms of Alzheimer's disease

1.7.2018 - 30.6.2020

Urban Košak


IJS dr. Dušan Turk 
FFA dr. Janez Mravljak

IJS dr. Dušan Turk 
FFA dr. Janez Mravljak