National projects

Neurodegenerative diseases, including Alzheimer's disease (AD), pose a serious healthcare threat with the staggering number of patients diagnosed with these disorders. The therapy is currently limited to palliative care and relief of the symptoms with numerous novel drugs in the pipeline. Among these, multifunctional ligands are focused on targeting multiple pathologies involved in the AD progress...

Ion channels are now considered unconventional, promising oncological targets, whose expression is often altered in cancer cells and which areemerging as critical players in tumorigenesis. The idea of targeting Kv1.3 ion channels directly in mitochondria, whose function critically depends onion fluxes and which are crucial for both cell survival and apoptosis, could...

Scientific background and problem identification. Vaginal infections are the most common reason women seek medical help and can cause serioushealth consequences, such as pelvic inflammatory disease, increased risk of sexually transmitted infections, and adverse pregnancy outcomes. Themost common vaginal infections are bacterial vaginosis and vaginal candidiasis, bot...

Intracellular targets of the innate immune system that can be modulated by small molecule agents, which offer numerous advantages compared to large biopharmaceuticals, represent big opportunities in pharmacy and innovative possibility to reverse the immune tolerance in the treatment of cancer patients. One of the most important aforementioned targets are Toll-like r...