National projects
Range:
Nanotheranostics based on magneto-responsive materials
Various types of cancers represent a great challenge to the health care system nowadays, since 3 million people are diagnosed for cancer annually in Europe. The efficacy of available anticancer medicines and therapeutic approaches is limited and often associated with serious side effects due to unspecific drug distribution in a human body. This problem can be preven...
Optimization of nitroxoline-based inhibitors of cathepsin B as potential drugs for the treatment of cancer
Human cathepsin B is a lysosomal cysteine protease that has many house-keeping functions, such as intracellular proteolysis. It can act as both an endopeptidase and an exopeptidase, a characteristic that is attributed to a 21-amino-acid insertion above the active site. Dysregulation of cathepsin B activity is associated with many pathological states. The most thorou...