National projects

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1.03 Natural sciences and mathematics / Biology
1.04 Natural Sciences and mathematics/Chemistry
1.04.02 Natural sciences and mathematics / Chemistry / Structural chemistry
1.05 Natural sciences and mathematics/Biochemistry and molecular biology
1.07. Natural sciences and mathematics / Computer intensive methods and applications
1.09 Pharmacy
1-09 Natural sciences and Mathematics - Pharmacy
2.04 Ingeeniring Sciences Technologies / Material Science and Technology
2.05.02 Engineering sciences and technologies/Mechanics/Experimental mechanics
2.06 Engineering sciences and technologies / Systems and cybernetics
2.13 Engineering sciences and technologies / Process engineering
3.00 Medical Sciences
3.01 Medical sciences/ Microbiology and immunology
3.03 Medical sciences/ Neurobiology
3.04 Medical Sciences/Oncology
3.05 Medical sciences / Human reproduction
3.06 Medical sciences / Cardiovascular system
3.07 Medical sciences/Metabolic and hormonal disorders
3.08 Medical Sciences / Public Healt
3.08 Medical Sciences / Public Health
4.00 Biotechnical Sciences
4.01.02 Biotechnical sciences / Forestry, wood and paper technology / Wood technology
4.03 Biotechnical sciences / Plant production
4.04.03 Biotechnical sciences / Veterinarian medicine / Therapy and health prevention of animals
4.06 Biotehniške vede
4.06 Biotechnical sciences / Biotechnology
4.06.01 Biotechnical sciences-Biotechnology-Recombinant DNA technology
4.06.02 Biotechnical sciences / Biotechnology / Bio-engineering
4.06.04 Biotechnical sciences/Biotechnology/Microbe biotechnology


Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity

Cancer remains an important cause of mortality and economic losses worldwide. The Bilateral Project provides excellent research in new anticancer discovery for the treatment of gastrointestinal (GI) carcinomas (colorectal, gastric, liver and pancreatic cancers), where hEag1 potassium channels are overexpressed in 75 to 100% cases. GI carcinomas are among the 10 most...

01. January 2019 - 31. December 2022 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of new carbamate-based imaging probes for cholinesterases

Cholinesterases (ChEs) are polymorphic serine hydrolases that catalyse the hydrolysis of neurotransmitter acetylcholine (ACh) and other esters. Two ChEs are found in vertebrates: acetylcholinesterase (AChE) and butyrycholinesterase (BChE). Both enzymes are involved not only in physiological processes but also in several pathophysiological processes (e.g.  Alzhe...

01. July 2018 - 31. March 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of novel Hsp90 inhibitors with anticancer activity

Scientific background and problem identification. Despite considerable improvements in treatment and survival times, cancer still remains one of the leading causes of mortality worldwide. Therefore, there is an urgent need to identify new drugs acting on new targets to improve treatment outcomes, especially against some aggressive types with no standard therapies, s...

01. January 2019 - 30. June 2023 | 1-09 Natural sciences and Mathematics - Pharmacy

Targeted covalent inhibitors: inhibiting monoamine oxidase through non-catalytic amino-acid residues

Monoamine oxidase (MAO) is a flavin-dependent enzyme that catalyzes the oxidation of amines, and has an important role in the homeostasis of biogenic and exogenic amines. Two isoforms of MAO (i.e., MAO-A and MAO-B) are present in most mammalian tissues and are distinguished by their sensitivities to acetylenic inhibitors clorgyline and L-deprenyl, and by their subst...

01. July 2019 - 30. June 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

Identification of non-peptidic inhibitors of the immunoproteasome using fragment based drug discovery methods

The proteasome is an intracellular protease that represents a vital part of the ubiquitin-proteasome system. It degrades a wide range of proteins and has critical functions in many biological processes including cell cycle control, apoptosis, inflammation, and signal transduction. The constitutive isoform (cCP) of the proteasome is expressed in all eukaryotic cells ...

01. November 2017 - 31. October 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease

Periodontal disease is perhaps the most common human afflictions, and through its local and systemic effects, it can considerably deteriorate the overall quality of person’s life. Periodontal disease is a biofilm-induced chronic inflammation of the periodontium, where two factors are specifically linked with its pathogenesis: (i) a shift in the oral microbiota...

01. July 2018 - 30. June 2022 | 1-09 Natural sciences and Mathematics - Pharmacy

Butyrylcholinesterase inhibitors for alleviating symptoms of Alzheimer's disease

Memory and cognitive deficits of patients with AD are the result of severely decreased brain levels of ACh. Currently approved ChEs inhibitors in AD therapy (donepezil, galantamine and rivastigmine) alleviate symptoms of the disease by increasing brain levels of ACh. They achieve this by preventing the breakdown of ACh through inhibition of the enzymes that hydrolyz...

01. July 2018 - 30. June 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

New anticancer leads for emerging cancer target potassium ion channels hEag1 and its validation in lymphoma tumors

Cancer remains an important cause of mortality and economic losses worldwide. Non-Hodgkin lymphoma (NHL) is among the 10 most-frequent forms of cancer in the EU and have the bad prognosis with the current therapeutic options. NHLs are a very heterogeneous group of disorders that comprise some very aggressive subtypes, with no standard for therapy. Even for individua...

01. July 2018 - 30. June 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

Discovery of new inhibitors of bacterial peptidoglycan biosynthesis enzymes MurA and MurB

Nowadays, we are in a transition era where it is evident that therapy of bacterial infections is not a trivial task, understood by modern medicine and supplied with abundant medicines. Emergence of bacterial resistance, globalisation and access to modern medicinal practice together with a decreasing output of antibacterial discovery pipeline, projects a major concer...

01. May 2017 - 30. April 2019 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of multifunctional compounds for treatment of Alzheimer's disease

The ageing of the population has resulted in an increase in the number of people with age-related diseases such as dementia. With more than 35 million people affected worldwide, Alzheimer’s disease (AD) is the most prominent form of senile dementia. The number of patients afflicted with this progressive neurodegenerative disorder will continue to grow and is e...

30. April 2017 - 30. April 2020 | 1-09 Natural sciences and Mathematics - Pharmacy