The aim of the proposed project is to develop safe theranostic lactic acid bacteria (ProbioTheranostics) that will be engineered with the ability to specifically target colorectal cancer cells, localize the tumor position using fluorescence imaging, and treat the colorectal cancer by exerting anti-inflammatory activity and modulating the composition of microbiota. P...

01. July 2018 - 30. June 2021 | 4.06 Biotechnical sciences / Biotechnology

Improvement of immunotherapeutic potential of NK cells through modulation of cystatin F

The effectiveness of conventional therapeutic modalities, including chemotherapy and radiotherapy, is limited due to drug resistance acquired by tumor cells during systemic treatment. Moreover, convenient antitumor drugs are practically ineffective against cancer stem cells, which represent a dormant pool of cells able to induce tumor recurrence. Cancer immunotherap...

01. July 2019 - 30. June 2022 | 4.06 Biotechnical sciences / Biotechnology

Biotechnological potential of selected microorganisms from Sečovlje Saltpans for application in cosmetics products

Blue Growth (BG) and sustainable blue strategy, including Marine (blue) biotechnology (MBT), are the long-term strategies to support sustainable growth. The global market for MBT has the potential to reach €5.5 Billion by 2025 and Europe is recognised as a high-potential region with largely unexplored marine resources. Since the global population`s median age i...

01. October 2022 - 30. September 2025 | 4.06 Biotechnical sciences / Biotechnology