Muscle cell secretom and bone cells interplay in osteosarcopenia (MiKOSA)
01. October 2022 - 30. September 2025 | 3.07 Medical sciences/Metabolic and hormonal disorders
Osteosarcopenia (OSA) affects 5-37% of community-dwelling older people (≥65 years) and is diagnosed at even higher rates in people with lowenergy trauma (osteoporotic) bone fractures (7.1–96.3%). There are no diagnostic biochemical markers available and no approved pharmacological agents for treatment of sarcopenia so far. With the present project, we aim t...
Identification of new expression regulators of RANKL, a key molecule not only in bone remodelling
01. January 2016 - 31. December 2018 | 3.07 Medical sciences/Metabolic and hormonal disorders
Receptor activator of nuclear factor-κB ligand (RANKL) is a part of the RANKL/RANK/OPG system which plays a crucial role in bone resorption and several other physiological processes. RANKL deregulation has been implicated in osteoporosis (OP), osteoarthritis (OA), autoimmune diseases, chronic inflammatory diseases and various cancers, leading to approval of de...