National projects

The development of drug‑resistant bacteria is an unavoidable outcome of widespread antibacterial chemotherapy of infectious diseases. Drug discovery programs directed against proteins considered essential for in vivo bacterial viability have yielded few new therapeutic classes of antibiotics, therefore treatment options for combating bacteria resistant to multiple d...

In nature, the extracellular matrix, which encloses bacterial cells, has a vital role for normal cell functioning. Such confinement serves as protection against predators and antimicrobial agents, allows the establishment of high cell densities and co-aggregation of different types of cells and provides a matrix, where different bioactive molecules can concentrate. ...