National projects
Range:
The Role and Potential Application of Immunomodulatory Mesenchymal Stem Cells in COVID- 19 Disease
The declared pandemic caused by new SARS-CoV-2 virus in 2020, did not catch the research organizations and pharmaceutical companies completely unprepared. Many scientific groups have already carried out research that was indirectly addressing the challenges facing the international health systems of today. In Slovenia, high level of scientific and professional healt...
01. October 2021 - 30. September 2024 | 3.01 Medical sciences/ Microbiology and immunology
Recombinant probiotics as bio-alternative antimicrobial approach against Clostridioides difficile
Clostridioides difficile infections represent a growing and serious health threat, particularly for the elderly and immune-compromised patients in the hospital setting. C. difficile causes a spectrum of pathological conditions ranging from mild self-limiting diarrhea, to serious diarrhea, pseudomembraneous colitis and potentially lethal fulminant colitis. C. diffici...
01. October 2021 - 30. September 2024 | 4.06 Biotehniške vede
Autologous immunohybridomas and advanced treatment of stage II and III triple-negative breast cancer
Breast cancer (BC) is a significant and common disease with a negative effect prevalently on women health, and the second most deadly type of cancer in females. BC is a highly heterogeneous disease due to its diverse morphological features, variable clinical outcomes and responses to currently available therapeutic options. Due to its high degree of heterogene...
01. October 2021 - 30. September 2024 | 3.01 Medical sciences/ Microbiology and immunology
Development of new inhibitors of bacterial topoisomerases to overcome antimicrobial resistance
In recent years, we observed an alarming increase in life-threatening infections due to resistant Gram-positive and Gram-negative pathogens and mycobacteria. Resistance has evolved to every single antibacterial drug that has been introduced to the clinic, which strongly limits our treatment options. New antibacterials specifically aimed at resistant infe...
01. October 2021 - 30. September 2024 | 1-09 Natural sciences and Mathematics - Pharmacy
MTAvsAMR: new MultiTargeting Antibiotics against AntiMicrobial Resistance
There is an urgent need for new therapies and new antibiotics to treat deadly infections caused by so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), which are often resistant to available antibiotics. Antimicrobial resistance (AMR) is ...
30. September 2021 - 30. September 2024 | 1-09 Natural sciences and Mathematics - Pharmacy
The kiss of death for key apoptosis players: development of BCL-2 and BAX PROTACs
The intrinsic (mitochondrial) apoptosis pathway is a physiologically dominant form of cell death and is controlled by the BCL-2 family of proteins. The members of this family have opposing effects as some of them promote and others prevent mitochondria-dependent apoptosis. The cross-talk within this family, which is governed by protein-protein interactions between p...
01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy
Development of innate immune receptor-targeting chimeras as custom-tailored vaccine adjuvants
Currently, our world is facing an acute shortage of novel vaccine adjuvants. Adjuvants enhance the immunogenicity of vaccines, therefore they constitute essential components of vaccines. They are needed not only to increase the magnitude of the response but also to guide the type of response to produce the most effective type of immunity against distinct pathogens/t...
01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy