National projects
Range:
Receptors for toxins of plant pathogens
Losses in crop production due to plant diseases average 20 % worldwide and severely limit production, quality, and safety of food. The main culprits, besides viruses, are fungi, bacteria and oomycetes. Practice of crop protection has been progressively reoriented towards reduction of a number of active ingredients in pesticides to those that are more selective and l...
01. January 2016 - 31. December 2018 | 1.05 Natural sciences and mathematics/Biochemistry and molecular biology
Efficacy of bacteriophages for treatment of extracellular and intracelular bacterial infections of implantants
Goal of the project is to investigate possibility of bacteriophage therapy in periprosthetic joint infections (PJI) treatment. The number of joint implants is increasing every year, as they nearly eliminate pain and contribute significantly to better mobility of the patients affected with end stage joint derangements. Along with increasing number of patients with jo...
01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy
Role of APOBEC proteins in the oncogenesis of HPV viruses
Human papillomaviruses (HPV) are one of the most prevalent sensually transmitted pathogens, responsible for more than 5 % of all cancers in humans, including cervical cancer and HPV-associated head-and-neck cancer. APOBEC3 (A3) proteins are cytidine deaminases that are capable of DNA and RNA editing. DNA-editing activity represent a key part of the innate immune response to viral infections. Howev...
01. September 2020 - 31. August 2023 | 3.01 Medical sciences/ Microbiology and immunology
Structural insight into iodine metabolism
Iodine is the heaviest essential trace element required by the higher living organisms. It is incorporated in T3/T4 hormones responsible for regulation of basal metabolism of almost any cell. T3 and T4 hormones are produced in the thyroid gland. The thyroid hormone metabolism involves selenium containing deiodinases and additional selenoperoxidases and thioredoxin p...
01. January 2016 - 31. December 2018 | 1.05 Natural sciences and mathematics/Biochemistry and molecular biology
Selective mechanical removal of bacterial biofilms by conjugated magnetic nanoparticles
Biofilms are microbial communities protected by a self-synthesized layer of extracellular polymeric substance that form on surfaces. Biofilms protect the bacteria from the host immune system and enable them to persist in adverse environmental conditions. They are an important clinical and public health problem, as up to 80% of all bacterial infections in humans ar...
01. October 2022 - 30. September 2025 | 1-09 Natural sciences and Mathematics - Pharmacy
The Role and Potential Application of Immunomodulatory Mesenchymal Stem Cells in COVID- 19 Disease
The declared pandemic caused by new SARS-CoV-2 virus in 2020, did not catch the research organizations and pharmaceutical companies completely unprepared. Many scientific groups have already carried out research that was indirectly addressing the challenges facing the international health systems of today. In Slovenia, high level of scientific and professional healt...
01. October 2021 - 30. September 2024 | 3.01 Medical sciences/ Microbiology and immunology
Recombinant probiotics as bio-alternative antimicrobial approach against Clostridioides difficile
Clostridioides difficile infections represent a growing and serious health threat, particularly for the elderly and immune-compromised patients in the hospital setting. C. difficile causes a spectrum of pathological conditions ranging from mild self-limiting diarrhea, to serious diarrhea, pseudomembraneous colitis and potentially lethal fulminant colitis. C. diffici...
01. October 2021 - 30. September 2024 | 4.06 Biotehniške vede