National projects

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1.03 Natural sciences and mathematics / Biology
1.04 Natural Sciences and mathematics/Chemistry
1.04.02 Natural sciences and mathematics / Chemistry / Structural chemistry
1.05 Natural sciences and mathematics/Biochemistry and molecular biology
1.07. Natural sciences and mathematics / Computer intensive methods and applications
1.09 Pharmacy
1-09 Natural sciences and Mathematics - Pharmacy
2.04 Ingeeniring Sciences Technologies / Material Science and Technology
2.05.02 Engineering sciences and technologies/Mechanics/Experimental mechanics
2.06 Engineering sciences and technologies / Systems and cybernetics
2.13 Engineering sciences and technologies / Process engineering
3.00 Medical Sciences
3.01 Medical sciences/ Microbiology and immunology
3.03 Medical sciences/ Neurobiology
3.04 Medical Sciences/Oncology
3.05 Medical sciences / Human reproduction
3.06 Medical sciences / Cardiovascular system
3.07 Medical sciences/Metabolic and hormonal disorders
3.08 Medical Sciences / Public Healt
3.08 Medical Sciences / Public Health
4.00 Biotechnical Sciences
4.01.02 Biotechnical sciences / Forestry, wood and paper technology / Wood technology
4.03 Biotechnical sciences / Plant production
4.04.03 Biotechnical sciences / Veterinarian medicine / Therapy and health prevention of animals
4.06 Biotehniške vede
4.06 Biotechnical sciences / Biotechnology
4.06.01 Biotechnical sciences-Biotechnology-Recombinant DNA technology
4.06.02 Biotechnical sciences / Biotechnology / Bio-engineering
4.06.04 Biotechnical sciences/Biotechnology/Microbe biotechnology


Autologous immunohybridomas and advanced treatment of stage II and III triple-negative breast cancer

Breast cancer (BC) is a significant and common disease with a negative effect prevalently on women health, and the second most deadly type of cancer in females. BC is a highly heterogeneous disease due to its diverse morphological  features, variable clinical outcomes and responses to currently available therapeutic options. Due to its high degree of heterogene...

01. October 2021 - 30. September 2024 | 3.01 Medical sciences/ Microbiology and immunology

Development of new inhibitors of bacterial topoisomerases to overcome antimicrobial resistance

In recent years, we observed an alarming increase in life-threatening infections due to resistant Gram-positive and Gram-negative pathogens and mycobacteria. Resistance has evolved to every single antibacterial   drug that has been introduced to the clinic, which strongly limits our treatment options. New antibacterials specifically aimed at resistant infe...

01. October 2021 - 30. September 2024 | 1-09 Natural sciences and Mathematics - Pharmacy

MTAvsAMR: new MultiTargeting Antibiotics against AntiMicrobial Resistance

There is an urgent need for new therapies and new antibiotics to treat deadly infections caused by so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), which are often resistant to available antibiotics. Antimicrobial resistance (AMR) is becoming an ...

01. October 2021 - 30. September 2024 | 1-09 Natural sciences and Mathematics - Pharmacy

The kiss of death for key apoptosis players: development of BCL-2 and BAX PROTACs

The intrinsic (mitochondrial) apoptosis pathway is a physiologically dominant form of cell death and is controlled by the BCL-2 family of proteins. The members of this family have opposing effects as some of them promote and others prevent mitochondria-dependent apoptosis. The cross-talk within this family, which is governed by protein-protein interactions between p...

01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of innate immune receptor-targeting chimeras as custom-tailored vaccine adjuvants

Currently, our world is facing an acute shortage of novel vaccine adjuvants. Adjuvants enhance the immunogenicity of vaccines, therefore they constitute essential components of vaccines. They are needed not only to increase the magnitude of the response but also to guide the type of response to produce the most effective type of immunity against distinct pathogens/t...

01. September 2020 - 31. August 2023 | 3.01 Medical sciences/ Microbiology and immunology

Photochemistry toolbox for discovery of advanced ATP-competitive chemical probes with Topoisomerase IIalpha inhibitory activity

Due to an ageing population, the challenges associated with cancer treatment are growing. The use of conventional chemotherapeutic agents is often limited because of their side effects. Moreover, resistance of cancer cells to chemotherapeutic drugs often results in failure of treatment. The project aims to contribute to the discovery and development of new anticance...

01. January 2021 - 31. December 2023 | 1-09 Natural sciences and Mathematics - Pharmacy

A Covalent Approach Against Antibiotic Resistance

The increased frequency of resistance among human bacterial pathogens represents a serious public threat in the treatment of infectious diseases. The United Nations, the World Health Organisation and the European Commission, have recently declared antimicrobial resistance (AMR) as a serious global threat to public health that has a tremendous impact on healthcare ex...

01. January 2021 - 31. December 2023 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of antibacterial compounds targeting validated enzymes in peptidoglycan biosynthesis

Infections caused by antibiotic-resistant bacteria continue to challenge health-care systems worldwide. We face a growing resistance of Gram-positive and Gram-negative pathogens that cause infections in hospitals and in the community, with the so-called antibiotic-resistant ‘superbugs’ that now represent a major global health problem. The obstacles of ha...

01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy

Modular asymmetric total synthesis of bioactive multi-chiral natural products

Bioactive compounds featuring natural product-inspired three-dimensional molecular architectures exhibit higher rate of clinical success compared to synthetically less challenging flat aromatic drug candidates. Accessing such complex multi-chiral scaffolds is a daring task and is often precluded by the limitations of organic chemistry or avoided by medicinal chemist...

01. September 2020 - 31. August 2022 | 1.04 Natural Sciences and mathematics/Chemistry

Radiopharmaceuticals with antagonistic activity on CCK2R

Background. Nuclear medicine investigations have an integral role in timely identification and confirmation of cancer, staging, follow-up of treatment efficiency and identification of the disease relapse. Certain tumour types and entities can be visualized by nuclear medicine imaging techniques because of the (over)expression of different receptors for certain regul...

01. September 2020 - 31. August 2023 | 1-09 Natural sciences and Mathematics - Pharmacy