National projects
Range:
Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity
Cancer remains an important cause of mortality and economic losses worldwide. The Bilateral Project provides excellent research in new anticancer discovery for the treatment of gastrointestinal (GI) carcinomas (colorectal, gastric, liver and pancreatic cancers), where hEag1 potassium channels are overexpressed in 75 to 100% cases. GI carcinomas are among the 10 most...
01. January 2019 - 31. December 2022 | 1-09 Natural sciences and Mathematics - Pharmacy
Development of new carbamate-based imaging probes for cholinesterases
Cholinesterases (ChEs) are polymorphic serine hydrolases that catalyse the hydrolysis of neurotransmitter acetylcholine (ACh) and other esters. Two ChEs are found in vertebrates: acetylcholinesterase (AChE) and butyrycholinesterase (BChE). Both enzymes are involved not only in physiological processes but also in several pathophysiological processes (e.g. Alzhe...
01. July 2018 - 31. March 2021 | 1-09 Natural sciences and Mathematics - Pharmacy
Development of novel Hsp90 inhibitors with anticancer activity
Scientific background and problem identification. Despite considerable improvements in treatment and survival times, cancer still remains one of the leading causes of mortality worldwide. Therefore, there is an urgent need to identify new drugs acting on new targets to improve treatment outcomes, especially against some aggressive types with no standard therapies, s...
01. January 2019 - 30. June 2023 | 1-09 Natural sciences and Mathematics - Pharmacy
Elucidating the role of immunoproteasome in platelet-driven immune response
The development of cancer metastasis is a disease hallmark, which predicts a poor outcome. Identifying novel therapeutic approaches that impair the immunosuppressive tumour microenvironment and enhance the immune response is of pivotal need. Herein, we propose a novel pharmacological target in shaping these processes, namely the immunoproteasome. Immunoproteasome is...
01. July 2019 - 30. June 2023 | 3.01 Medical sciences/ Microbiology and immunology
Targeted covalent inhibitors: inhibiting monoamine oxidase through non-catalytic amino-acid residues
Monoamine oxidase (MAO) is a flavin-dependent enzyme that catalyzes the oxidation of amines, and has an important role in the homeostasis of biogenic and exogenic amines. Two isoforms of MAO (i.e., MAO-A and MAO-B) are present in most mammalian tissues and are distinguished by their sensitivities to acetylenic inhibitors clorgyline and L-deprenyl, and by their subst...
01. July 2019 - 30. June 2021 | 1-09 Natural sciences and Mathematics - Pharmacy
NOBIL - Novel Biomarkers in Leukemia
The project NOBIL will therefore focus on the translational research in oncology to contribute to the discovery of novel biomarkers and innovative individualized therapeutic approaches to overcome the resistance of leukemia. The proposed project emerged from ongoing effort of academics and clinicians at Faculty of pharmacy (prof. Mlinarič-Raščan) and Institut...
01. May 2018 - 30. April 2020 | 3.04 Medical Sciences/Oncology
Identification of non-peptidic inhibitors of the immunoproteasome using fragment based drug discovery methods
The proteasome is an intracellular protease that represents a vital part of the ubiquitin-proteasome system. It degrades a wide range of proteins and has critical functions in many biological processes including cell cycle control, apoptosis, inflammation, and signal transduction. The constitutive isoform (cCP) of the proteasome is expressed in all eukaryotic cells ...
01. November 2017 - 31. October 2020 | 1-09 Natural sciences and Mathematics - Pharmacy
Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease
Periodontal disease is perhaps the most common human afflictions, and through its local and systemic effects, it can considerably deteriorate the overall quality of person’s life. Periodontal disease is a biofilm-induced chronic inflammation of the periodontium, where two factors are specifically linked with its pathogenesis: (i) a shift in the oral microbiota...
01. July 2018 - 30. June 2022 | 1-09 Natural sciences and Mathematics - Pharmacy