National projects
Range:
Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease
Neurodegenerative diseases, including Alzheimer's disease (AD), pose a serious healthcare threat with the staggering number of patients diagnosed with these disorders. The therapy is currently limited to palliative care and relief of the symptoms with numerous novel drugs in the pipeline. Among these, multifunctional ligands are focused on targeting multiple pathologies involved in the AD progress...
Development of new antibiotics simultaneously targeting beta-lactamases and penicillin-binding proteins
β-Lactam antibiotics remain the single most important antibiotic class in use worldwide. The clinical longevity of β-lactams is threatened by bacterial resistance enzymes (i.e. β-lactamases, BL) that can inactivate them by hydrolysis. We face a growing resistance to Gram-positive and Gram-negative pathogens that cause infections in hospitals and the c...