National projects

The project is focused on the search for neurotoxic compounds in a group of chemicals that are used in industry in large quantities, using in silico methods. It is divided into four main tasks: setting up a set of chemicals, arranging their toxicological profiles, selecting candidates (one to five) by reviewing and comparing existing data and presenting a dossier fo...

The development of drug‑resistant bacteria is an unavoidable outcome of widespread antibacterial chemotherapy of infectious diseases. Drug discovery programs directed against proteins considered essential for in vivo bacterial viability have yielded few new therapeutic classes of antibiotics, therefore treatment options for combating bacteria resistant to multiple d...

The effectiveness of conventional therapeutic modalities, including chemotherapy and radiotherapy, is limited due to drug resistance acquired by tumor cells during systemic treatment. Moreover, convenient antitumor drugs are practically ineffective against cancer stem cells, which represent a dormant pool of cells able to induce tumor recurrence. Cancer immunotherap...

Forest-based industries, especially pulp and paper industries, produce huge quantities of bark during primary processing activities. In 2017 alone, the European pulp and paper industry used close to 149 million cubic meters of wood. The bark reduces the quality of wood products and is removed and mainly burned for energy production. In pulp and paper industries, a w...

Computer intensive methods and applications is extremely propulsive area of scientific research in which the use of supercomputers and computer clusters is used to solve the most demanding computational problems in theoretical and applied research in natural and technical sciences. We deal with solving of various types of problems, such as, structure and dynamics of...

The cell wall of Gram-positive bacteria is composed of proteins and peptidoglycan with the protruding secondary polysaccharides, which differ in the chemical composition and structure among various species. The cell wall secondary polysaccharides are covalently attached to the peptidoglycan and can account for more than a half of the total cell wall mass. They form ...

Blue Growth (BG) and sustainable blue strategy, including Marine (blue) biotechnology (MBT), are the long-term strategies to support sustainable growth. The global market for MBT has the potential to reach €5.5 Billion by 2025 and Europe is recognised as a high-potential region with largely unexplored marine resources. Since the global population`s median age i...

https://cris.cobiss.net/ecris/si/en/project/20017

Ion channels are now considered unconventional, promising oncological targets, whose expression is often altered in cancer cells and which areemerging as critical players in tumorigenesis. The idea of targeting Kv1.3 ion channels directly in mitochondria, whose function critically depends onion fluxes and which are crucial for both cell survival and apoptosis, could...

Scientific background and problem identification. Vaginal infections are the most common reason women seek medical help and can cause serioushealth consequences, such as pelvic inflammatory disease, increased risk of sexually transmitted infections, and adverse pregnancy outcomes. Themost common vaginal infections are bacterial vaginosis and vaginal candidiasis, bot...