Our research is encompassed in the following research themes.

Pre-formulation and formulation

  • Physico-chemical characterization: evaluation of polymorphs, pKa, logP, solubility in water and physiologic media
  • Amorphicity: detection and quantification of amorphous material content concerning suitability and stability of API and dosage forms
  • Solubilization of poorly soluble compounds (solid dispersions, surfactants, hydrotropic substances)
  • High throughput permeability screening with parallel artificial membrane permeability assay (PAMPA)
  • BCS classification: determination of aqueous solubility, drug permeability mechanism and presystemic gut wall metabolism in Sweetana Grass side-by-side diffusion chambers with isolated intestinal tissue or Caco-2 monolayers
  • Evaluation of pharmaceutical excipients potential to influence intestinal drug absorption
  • Prediction of drug-drug and drug-food interactions during intestinal absorption and pre-systemic metabolism (isolated intestinal tissue, precision-cut liver slices and HepG2 cell cultures)

Drug stability

  • Compatibility: early assessment of (in)compatibility between API and excipients for shorter development timelines of experimental and finished dosage forms
  • Water sorption: water content sorbed by API or excipients enabling anticipation of possible instability or wetting problems
  • Chemical and physical stability: intrinsic stability characterization for scientifically based dosage form design, and confirmatory stability testing of API and finished products

Drug dissolution

  • USP Apparatus I, II and IV, Custom designed biorelevant flow-through dissolution model
  • Physiological model of drug dissolution: dissolution experiments at conditions close to physiological (pH, volumes, flows, ionic strength)
  • Mathematical models of gastric emptying and gastrointestinal transit
  • In vitro – in vivo correlation

Analytical support

  • Development of selective and sensitive assays for determination of drugs, metabolites, degradation products and endogenous compounds in various matrices
  • Validation of analytical methods according to FDA and ICH recommendations
  • State-of-the-art instrumentation and automation equipment for sample analyses including 2 LC/MS/MS, several HPLCs with DAD, FD, RI and ECD, micro DSC, automated SPE stations, etc.

Drug metabolism

  • In vitro models of increasing complexity: recombinant enzymes, subcellular fractions, cell lines (Caco-2, Hep-G2), tissue slices (liver, intestine), side-by-side diffusion chambers

Bioavailability/bioequivalence and Pharmacokinetic/pharmacodynamic studies

Assistance through all stages of drug development (fundamental research, preclinical, clinical and post-marketing studies)

  • Study design and protocol development
  • Study monitoring and coordination with clinical sites
  • Bioanalytical services
  • Biostatistics
  • Final report and preparation of documentation for regulatory submission

Therapeutic drug monitoring and Personalized therapy

We collaborate with hospital services in TDM for drugs with a narrow therapeutic range and dose individualisation according to genetic polymorphisms and other factors


Application of pharmacokinetic, pharmacodynamic, pharmacokinetic/pharmacodynamic and disease progression models for optimising drug development, and therapeutic strategies, thereby increasing the safety and efficacy of pharmaceuticals in clinical settings

  • Pharmacokinetic and Pharmacodynamic data analysis 
  • Population analysis using nonlinear mixed effects modelling
  • Target mediated drug disposition
  • Modelling and simulation
  • Clinical trials simulation 

Do you need scientific answers to direct your compounds and therapeutic strategies a step further in the development process?