National projects

Comprehensive characterization of GWAS hits – pipeline to novel drug targets for anabolic treatment of osteoporosis (GWASforAna)

Osteoporosis is the most common skeletal disease with deterioration of bone structure and increased risk of bone fractures. Even though the ethiology of osteoporosis has been well studied, effective personalized approach to prevention, diagnosis and particular anabolic drugs to prevent bone fractures are still lacking and there is an urgent need to identify novel ta...

01. July 2019 - 30. June 2022 | 3.07 Metabolic and hormonal disorders

Identification of new expression regulators of RANKL, a key molecule not only in bone remodelling

Receptor activator of nuclear factor-κB ligand (RANKL) is a part of the RANKL/RANK/OPG system which plays a crucial role in bone resorption and several other physiological processes. RANKL deregulation has been implicated in osteoporosis (OP), osteoarthritis (OA), autoimmune diseases, chronic inflammatory diseases and various cancers, leading to approval of denosumab, a monoclonal antibody t...

31. December 2015 - 30. December 2018 | 3.07 Metabolic and hormonal disorders