Genes, hormones and personality changes in metabolic disorders

Code:

P3-0298 (B)

Range:

01. January 2015 - 31. December 2018

Range:

2,07 FTE

Leader:

Andrej Janež

Field:

3.00 Medical Sciences

Research Organisation:

https://cris.cobiss.net/ecris/si/sl/project/9727

Researchers:

https://cris.cobiss.net/ecris/si/sl/project/9727

Content:

https://cris.cobiss.net/ecris/si/sl/project/9727

Abstract:

Our programme is based on activities and achievements in the last two decades in the field of chronic metabolic disorders such as osteoporosis and bone metabolism, polycystic ovary syndrome (PCOS), diabetes type 2 (and to a lesser degree type 1) and insulin resistance as a common component of the last two disorders. The majority of our activities will be further research in the directions where we already have results or are trying to get answers on new questions that appeared as a consequence of our results. We will proceed with adding insight in connections between new polymorphisms and bone mineral density (BMD), adding new dependent variables such as fracture risk calculations and indirect estimations of bone microarchitecture (trabecular bone score – TBS). A new topic will be epigenetic research in bone pathology. We intend to broaden our “bone” research to metastatic bone disease and chondrocyte pathology. A connection between bone field and diabetes will be another research topic: messengers in  feed-back loops between bone and energy metabolism (cytokines, adipocytokins). Another research topic will be the link between type 1 diabetes and PCOS. In the field of PCOS new therapies with ovary as therapeutic target are planned.