Genes, hormones and personality changes in metabolic disorders
Code:
P3-0298
Range:
01. January 2019 - 31. December 2024
Range:
2,07 FTE
Leader:
Andrej Janež
Field:
3.00 Medical Sciences
Research Organisation:
http://www.sicris.si/public/jqm/prg.aspx?lang=eng&opdescr=search&opt=2&subopt=703&code1=cmn&code2=auto&psize=1&hits=1&page=1&count=&search_term=Geni,%20hormonske%20in%20osebnostne%20spremembe%20pri%20metabolnih%20motnjah&id=17650&slng=&order_by=
Researchers:
http://www.sicris.si/public/jqm/prg.aspx?lang=eng&opdescr=search&opt=2&subopt=702&code1=cmn&code2=auto&psize=1&hits=1&page=1&count=&search_term=Geni,%20hormonske%20in%20osebnostne%20spremembe%20pri%20metabolnih%20motnjah&id=17650&slng=&order_by=
Citations for bibliographic records:
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Content:
http://www.sicris.si/public/jqm/prg.aspx?lang=eng&opdescr=search&opt=2&subopt=705&code1=cmn&code2=auto&psize=1&hits=1&page=1&count=&search_term=Geni,%20hormonske%20in%20osebnostne%20spremembe%20pri%20metabolnih%20motnjah&id=17650&slng=&order_by=
Abstract:
Our programme is based on activities and achievements in the last two decades in the field of chronic metabolic disorders such as osteoporosis and bone metabolism, polycystic ovary syndrome (PCOS), diabetes type 2 (and to a lesser degree type 1) and insulin resistance as a common component of the last two disorders. The majority of our activities will be further research in the directions where we already have results or are trying to get answers on new questions that appeared as a consequence of our results. We will proceed with adding insight in connections between new polymorphisms and bone mineral density (BMD), adding new dependent variables such as fracture risk calculations and indirect estimations of bone microarchitecture (trabecular bone score – TBS). A new topic will be epigenetic research in bone pathology. We intend to broaden our “bone” research to metastatic bone disease and chondrocyte pathology. A connection between bone field and diabetes will be another research topic: messengers in feed-back loops between bone and energy metabolism (cytokines, adipocytokins). Another research topic will be the link between type 1 diabetes and PCOS. In the field of PCOS new therapies with ovary as therapeutic target are planned.
Changed: 21. July 2016