Education:
- 2004–2008: Grammar School, Ravne na Koroškem
- 2008–2013: Uniform Master’s Study Programme Pharmacy (Master of Pharmacy), University of Ljubljana
- 2013–2017: Doctoral Programme Biomedicine, Field: Pharmacy (Ph.D), University of Ljubljana
Academic ranks:
- 2013–2020 : Assistant in the field of Medicinal Chemistry
- 2020–: Assistant Professor in the field of Medicinal Chemistry
Employment:
- 2013: researcher (in collaboration with Lek d.d)
- 2013–2017: young researcher at the Chair of Pharmaceutical Chemistry Faculty of Pharmacy
- 2017– : researcher on projects
Teaching activities:
- Co-supervisor of students for Master's thesis at Faculty of Pharmacy
- Uniform Master’s Study Programme Pharmacy: assistant on practical course Analysis and Control of Active Substances
Projects:
- researcher on projects of Slovenian Research Agency (Medicinal Chemistry, drug design)
- Principal investigator on Slovenian Research Agency project (1st July 2019 – 30th June 2021)
Research:
- Structure- and ligand-based drug design
- Design and synthesis of monoamine oxidase and butyrylcholinesterase inhibitors
- Design and synthesis of multifunctional ligands for neurodegenerative disorders
Prizes and awards, scholarships:
- 2013: The Faculty of Pharmacy Prešeren Award for research work
- 2015: Scholarship of French Insititute in Slovenia for research work in France (1 months)
- 2016: Rector’s award for best innovation of University of Ljubljana
- 2017: Krka award for doctoral thesis
International research visits:
- 2015: Institute for Structural Biology IBS, Grenoble, France (supervisor: dr. Jacques-Philippe Colletier), 1 month
- 2016 in 2017: Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina (supervisor: prof. dr. Mariel Marder), 1 month
- 2017: University of Pavia, Pavia, Italy (supervisor, prof. dr. Claudia Binda), 2 months
Papers and citations:
- 556 citations (January 2021, Scopus)
- H-index: 16 (January 2021, Scopus)
Top publications:
- Knez D et al., J Med Chem, 2020; 63: 1361
- Meden A, Knez D et al., Chem Comm, 2019; 55: 3765
- Knez D et al., Curr Alzheimer Res, 2019; 16: 801
- Knez D et al., Eur J Med Chem, 2018; 156: 598
- Košak U, Brus B, Knez D et al., J Med Chem, 2018; 61: 119
- Knez D et al., Future Med Chem, 2017; 9: 811
- Sosič I, Gobec M, Brus V, Knez D et al., Angew Chem, 2016; 55: 5745
Patents:
- Knez D, Sova M, Gobec S. Disubtituted azetidines, pyrrolidines, piperidines and azepanes as inhibitors of monoamine oxidase b for the treatment of neurodegenerative diseases: EP3426634(B1), 2020-01-22, WO2018055096(A1), 2018-03-29.
- Brus B, Košak U, Knez D, et al., Disubstituted piperidine derivatives as butyrylcholinesterase inhibitors for use in the treatment of Alzheimer’s: EP3256128(B1), 2018-11-14, US10071964(B2), 2018-09-11.
- Sosič I, Gobec M, Brus B, Knez D, et al., Psoralen derivatives as non-peptidic inhibitors of chymotrypsin-like activity of the immunoproteasome: EP3256120(B1), 2018-11-14, WO2016151483(A1), 2016-09-29.
Full Bibliography |