Researchers from the Faculty of Pharmacy, Chair for Pharmaceutical Biology published an article in Journal of Allergy and Clinical Immunology - Impact Factor 13.26

Researchers from the Faculty of Pharmacy, Chair for Pharmaceutical Biology (Abida Zahirović, PhD student, first author; Mojca Lunder, head of the project and corresponding author and Borut Štrukelj) in collaboration with University Clinic for Lung Diseases and Allergy, Golnik, Slovenia (Peter Korošec, Peter Kopač and Ana Koren) published a short communication in Journal of Allergy and Clinical Immunology (Impact Factor 13.26).

In the article with the title:«Identification of bee venom Api m 1 IgE epitopes and characterization of corresponding mimotopes” they identified  for the first time two IgE epitopes of Api m 1. Synthesized  peptide mimotopes, corresponded to detected epitopes,  showed no allergenic activity. In contrast to bee venom and Api m 1, which stimulated predominantly type 2 cytokine response, mimotopes induced T cell secretion of type 1 cytokines, suggesting a shift from TH2 to TH1 immune response. Identified IgE epitopes enable better understanding of disease mechanism and their respective mimotopes provide an opportunity for development of safer, alternative immunotherapy for bee venom allergy.