National projects
Range:
Development of innate immune receptor-targeting chimeras as custom-tailored vaccine adjuvants
Currently, our world is facing an acute shortage of novel vaccine adjuvants. Adjuvants enhance the immunogenicity of vaccines, therefore they constitute essential components of vaccines. They are needed not only to increase the magnitude of the response but also to guide the type of response to produce the most effective type of immunity against distinct pathogens/t...
Elucidating the role of immunoproteasome in platelet-driven immune response
The development of cancer metastasis is a disease hallmark, which predicts a poor outcome. Identifying novel therapeutic approaches that impair the immunosuppressive tumour microenvironment and enhance the immune response is of pivotal need. Herein, we propose a novel pharmacological target in shaping these processes, namely the immunoproteasome. Immunoproteasome is...
Development of NOD2 agonists and dual NOD2/TLR7 agonistic conjugates as novel vaccine adjuvants
Currently, our world is facing an acute shortage of novel vaccine adjuvants. Adjuvants enhance the immunogenicity of vaccines, therefore they constitute essential components of vaccines. They are needed not only to increase the magnitude of the response but also to guide the type of response to produce the most effective type of immunity against distinct pathogens/t...