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National projects

NOBIL - Novel Biomarkers in Leukemia

The project NOBIL will therefore focus on the translational research in oncology to contribute to the discovery of novel biomarkers and innovative individualized therapeutic approaches to overcome the resistance of leukemia. The proposed project emerged from ongoing effort of academics and clinicians at Faculty of pharmacy (prof. Mlinarič-Raščan) and Institut...

01. May 2018 - 30. April 2020 | 3.04 Mecical Sciences/Oncology

Identification of non-peptidic inhibitors of the immunoproteasome using fragment based drug discovery methods

The proteasome is an intracellular protease that represents a vital part of the ubiquitin-proteasome system. It degrades a wide range of proteins and has critical functions in many biological processes including cell cycle control, apoptosis, inflammation, and signal transduction. The constitutive isoform (cCP) of the proteasome is expressed in all eukaryotic cells ...

01. November 2017 - 31. October 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease

Periodontal disease is perhaps the most common human afflictions, and through its local and systemic effects, it can considerably deteriorate the overall quality of person’s life. Periodontal disease is a biofilm-induced chronic inflammation of the periodontium, where two factors are specifically linked with its pathogenesis: (i) a shift in the oral microbiota...

30. June 2018 - 30. June 2021 | 1.09 Pharmacy

Inhibition of cathepsin X activity as a novel strategy for the treatment of Parkinson's disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by a progressive degeneration of the dopaminergic projection between the substantia nigra compacta (SNc) and the striatum with associated movement impairments. It represents a very important health issue, as there is no cure for this devastating disease. Although the eth...

01. July 2018 - 30. June 2021 | 3.03 3.03 Medical sciences/ Neurobiology

Butyrylcholinesterase inhibitors for alleviating symptoms of Alzheimer's disease

Memory and cognitive deficits of patients with AD are the result of severely decreased brain levels of ACh. Currently approved ChEs inhibitors in AD therapy (donepezil, galantamine and rivastigmine) alleviate symptoms of the disease by increasing brain levels of ACh. They achieve this by preventing the breakdown of ACh through inhibition of the enzymes that hydrolyz...

01. July 2018 - 30. June 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

New anticancer leads for emerging cancer target potassium ion channels hEag1 and its validation in lymphoma tumors

Cancer remains an important cause of mortality and economic losses worldwide. Non-Hodgkin lymphoma (NHL) is among the 10 most-frequent forms of cancer in the EU and have the bad prognosis with the current therapeutic options. NHLs are a very heterogeneous group of disorders that comprise some very aggressive subtypes, with no standard for therapy. Even for individua...

01. July 2018 - 30. June 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

Development of NOD2 agonists and dual NOD2/TLR7 agonistic conjugates as novel vaccine adjuvants

Currently, our world is facing an acute shortage of novel vaccine adjuvants. Adjuvants enhance the immunogenicity of vaccines, therefore they constitute essential components of vaccines. They are needed not only to increase the magnitude of the response but also to guide the type of response to produce the most effective type of immunity against distinct pathogens/t...

01. July 2018 - 30. June 2021 | 3.01 Medical sciences/ Microbiology and immunology

Razvoj novih zaviralcev encimov biosinteze peptidoglikana MurA in MurB (Slovene)

Within the research project, we are pursuing the identification of inhibitors of early steps in peptydoglycan biosynthesis, namely MurA and MurB enzymes. We are employing structure-based design, ligand-based design and fragment based techniques and methodologies and we are performing virtual screening. With the use of organic synthesis, we are preparing focused libr...

30. April 2017 - 30. April 2019 | 1-09 Natural sciences and Mathematics - Pharmacy

Razvoj multifunkcionalnih učinkovin za zdravljenje Alzheimerjeve bolezni (Slovene)

The ageing of the population has resulted in an increase in the number of people with age-related diseases such as dementia. With more than 35 million people affected worldwide, Alzheimer’s disease (AD) is the most prominent form of senile dementia. The number of patients afflicted with this progressive neurodegenerative disorder will continue to grow and is e...

30. April 2017 - 30. April 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

Preprečevanje rezistence tumorskih celic na antiproteazno terapijo z inhibitorji katepsina X (Slovene)

The progression of malignant diseases is associated with excessive activity of the proteolytic enzymes involved in tumor growth, angiogenesis, migration, invasion and metastasis. Among them is a group of cysteine cathepsins that are present in normal cells in endosomes and lysosomes and are responsible for intracellular protein catabolism. In tumor cells these enzym...

30. April 2017 - 30. April 2020 | 4.06.01 Biotechnical sciences-Biotechnology-Recombinant DNA technology