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National projects

Comprehensive characterization of GWAS hits – pipeline to novel drug targets for anabolic treatment of osteoporosis (GWASforAna)

Osteoporosis is the most common skeletal disease with deterioration of bone structure and increased risk of bone fractures. Even though the ethiology of osteoporosis has been well studied, effective personalized approach to prevention, diagnosis and particular anabolic drugs to prevent bone fractures are still lacking and there is an urgent need to identify novel ta...

01. July 2019 - 30. June 2022 | 3.07 Metabolic and hormonal disorders

Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity

Cancer remains an important cause of mortality and economic losses worldwide. The Bilateral Project provides excellent research in new anticancer discovery for the treatment of gastrointestinal (GI) carcinomas (colorectal, gastric, liver and pancreatic cancers), where hEag1 potassium channels are overexpressed in 75 to 100% cases. GI carcinomas are among the 10 most...

01. January 2019 - 31. December 2022 | 1.00 Natural sciences and mathematics

Development of new carbamate-based imaging probes for cholinesterases

Cholinesterases (ChEs) are polymorphic serine hydrolases that catalyse the hydrolysis of neurotransmitter acetylcholine (ACh) and other esters. Two ChEs are found in vertebrates: acetylcholinesterase (AChE) and butyrycholinesterase (BChE). Both enzymes are involved not only in physiological processes but also in several pathophysiological processes (e.g.  Alzhe...

01. April 2020 - 31. March 2021 | 1.09 Pharmacy

Development of novel Hsp90 inhibitors with anticancer activity

Chaperones are ubiquitous molecular machineries that maintain a balanced protein homeostasis (proteostasis) by continuously sampling and assessing the conformational state of polypeptides by a plethora of cellular processes from de novo, cotranslational and posttranslational folding of nascent polypeptides, polypeptide disaggregation and protein degradation. Several...

01. January 2019 - 30. December 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

Elucidating the role of immunoproteasome in platelet-driven immune response

The development of cancer metastasis is a disease hallmark, which predicts a poor outcome. Identifying novel therapeutic approaches that impair the immunosuppressive tumour microenvironment and enhance the immune response is of pivotal need. Herein, we propose a novel pharmacological target in shaping these processes, namely the immunoproteasome. Immunoproteasome is...

31. July 2019 - 30. July 2022 | 3.01 Medical sciences/ Microbiology and immunology

Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system

Healthy joints are of utmost importance for mobility and our activities of daily living. Degenerative disorders such as osteoarthritis, affect normal function of the joints hence impair independent mobility in affected individuals. Osteoarthritis results from a combination of the breakdown of the joint and the body’s attempted endogenous regenerative process t...

01. January 2019 - 31. December 2022 | 3.03 3.03 Medical sciences/ Neurobiology

Targeted covalent inhibitors: inhibiting monoamine oxidase through non-catalytic amino-acid residues

Monoamine oxidase (MAO) is a flavin-dependent enzyme that catalyzes the oxidation of amines, and has an important role in the homeostasis of biogenic and exogenic amines. Two isoforms of MAO (i.e., MAO-A and MAO-B) are present in most mammalian tissues and are distinguished by their sensitivities to acetylenic inhibitors clorgyline and L-deprenyl, and by their subst...

30. June 2019 - 01. July 2021 | 1-09 Natural sciences and Mathematics - Pharmacy

NOBIL - Novel Biomarkers in Leukemia

The project NOBIL will therefore focus on the translational research in oncology to contribute to the discovery of novel biomarkers and innovative individualized therapeutic approaches to overcome the resistance of leukemia. The proposed project emerged from ongoing effort of academics and clinicians at Faculty of pharmacy (prof. Mlinarič-Raščan) and Institut...

01. May 2018 - 30. April 2020 | 3.04 Mecical Sciences/Oncology

Identification of non-peptidic inhibitors of the immunoproteasome using fragment based drug discovery methods

The proteasome is an intracellular protease that represents a vital part of the ubiquitin-proteasome system. It degrades a wide range of proteins and has critical functions in many biological processes including cell cycle control, apoptosis, inflammation, and signal transduction. The constitutive isoform (cCP) of the proteasome is expressed in all eukaryotic cells ...

01. November 2017 - 31. October 2020 | 1-09 Natural sciences and Mathematics - Pharmacy

Nanomedicines with antibiotics and probiotics for local treatment of periodontal disease

Periodontal disease is perhaps the most common human afflictions, and through its local and systemic effects, it can considerably deteriorate the overall quality of person’s life. Periodontal disease is a biofilm-induced chronic inflammation of the periodontium, where two factors are specifically linked with its pathogenesis: (i) a shift in the oral microbiota...

30. June 2018 - 30. June 2021 | 1.09 Pharmacy