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General:
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E-mail:
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matej.sova@ffa.uni-lj.si
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Phone:
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+386 1 47 69 556
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Fax:
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+386 1 42 58 031
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Education:
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1998-2004
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Uniform master’s study programme Pharmacy (Master of Pharmacy)
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2004-2009
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Doctoral study programme Biomedicine, fields Pharmacy (Ph.D.) - young researcher at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2010
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Postdoctoral researcher at the Department of Medicinal Chemistry, School of Pharmacy, Leeds, UK
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Academic titles (ranks):
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2004-2012
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Assistant at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2012-2019
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Assistant Professor at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2019-present
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Associate Professor at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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Research interests:
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Ø design, synthesis and evaluation of small-molecule enzyme inhibitors
Ø indoleamine 2,3-dioxygenase inhibitors
Ø Toll-like receptors modulators
Ø inhibitors of bacterial cell wall biosynthesis (inhibitors of Mur enzymes, glycosyl transferase, Upps)
Ø monoamine oxidase inhibitors
Ø antitumor agents
Ø antimicotics
Ø cinnamic acid and derivatives
Ø cross-coupling reactions
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Expertise:
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Ø drug design and development
Ø organic chemistry, synthesis
Ø medicinal chemistry
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Contributions:
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Ø topic editor for journal Molecules
Ø author or co-author of more than 30 publications in peer-reviewed journals
Ø collaborative research between Faculty of Pharmacy and industry in Slovenia (Lek d.d., Krka d.d.); joint patent applications and patents
Ø referee for several journals from Wiley, Elsevier journals, American Chemical Society, Bentham Science Publishers, Springer, MDPI
Ø participation in numerous international scientific meetings
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Student supervision:
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Ø 5 undergraduate students
Ø more than 30 Master students
Ø 2 PhD students (Kaja Rožman 2014-2018, Ana Dolšak 2017-2021)
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Prizes and awards:
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Ø 2001 and 2003: Faculty commendations for the best students of the year
Ø 2004: The Faculty of Pharmacy Prešeren Award for research work
Ø 2009: Krka Pharmaceutical Company Award for doctoral thesis “Design and synthesis of hydroxyethylamines as inhibitors of peptidoglycan biosynthesis”
Ø 2016: Chamber of Commerce and Industry Golden Innovation Award – main Slovenian region (Ljubljana)
Ø 2016: Chamber of Commerce and Industry of Slovenia Golden Innovation Award (Slovenian National Award)
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Research projects:
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Ø 2004-present: member of the research programme P1-0208 »Medicinal chemistry: drug design, synthesis and evaluation«
Ø 2005-2010: researcher in European project "EUR-INTAFAR: Inhibition of new targets for fighting antibiotic resistance"; Integrated FP6 EU project; LSHM-CT-2004-512138
Ø 2009-2017: researcher in projects financed from Slovenian Research Agency:
- J4-2212 "Fungal cytochromes P450, involved in detoxification of plant defense molecules, as targets for novel antifungal agents"
- L1-4039 "Preclinical development of new antibacterial drugs"
- L1-6745 "Combating bacterial resistance: optimisation of bacterial cell wall biosynthesis inhibitors"
Ø 2006-2017: researcher in 5 industrial projects with Lek (3 papers and 5 international patents)
Ø 2017: industrial research project with Lek "The synthesis of impurities of antidiabetic drug"
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Lectures at international conferences or universities:
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Ø 2011: oral presentation at 7th Joint Meeting on Medicinal Chemistry in Catania, Italy
Ø 2017: lectures at Sapienza Universita di Roma, Italy (Erasmus+ staff mobility project)
Ø 29.6.2017: key-note lecture at 10th Joint Meeting on Medicinal Chemistry in Dubrovnik, Croatia
Ø 5.6.2019: lecture “Biological activities and research on cinnamic acid derivatives” at Lomonosov Moscow State University, A. N. Belozersky Research Institute of Physico-Chemical Biology, Moscow, Russia (bilateral project BI-RU/19-20-040)
Ø 23.7.2019: lecture “The research on Toll-like receptors and indolamine 2,3-dioxygenase - promising targets for cancer immunotherapy” at University of Minnesota, College of Pharmacy, Minneapolis, Minnesota, USA (bilateral project BI-US/18-20-087)
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PUBLICATIONS
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32 publications in peer-reviewed journals
http://izumbib.izum.si/bibliografije/A20191119131554-25490.html
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5 recent and/or most important papers:
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1.
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SOVA, Matej, FRLAN, Rok, GOBEC, Stanislav, ČASAR, Zdenko. Efficient and straightforward syntheses of two united states pharmacopeia sitagliptin impurities : 3-desamino-2,3- dehydrositagliptin and 3-desamino-3,4-dehydrositagliptin.
ACS omega, 2020, vol. 5(10), 5356-5364; https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b04393, doi: 10.1021/acsomega.9b04393.
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2020
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2.
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KNEZ, Damijan, COLETTIS, Natalia, IACOVINO, Luca G., SOVA, Matej, PIŠLAR, Anja, KONC, Janez, LEŠNIK, Samo, HIGGS, Josefina, KAMECKI, Fabiola, MANGIALAVORI, Irene, DOLŠAK, Ana, ŽAKELJ, Simon, TRONTELJ, Jurij, KOS, Janko, BINDA, Claudia, MARDER MARIEL, Nora, GOBEC, Stanislav.
Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B.
Journal of medicinal chemistry, 2020, vol. 63(3,) 1361-1387; https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01886,
doi: 10.1021/acs.jmedchem.9b01886.
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2020
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3.
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DOLŠAK, Ana, ŠVAJGER, Urban, LEŠNIK, Samo, KONC, Janez, GOBEC, Stanislav, SOVA, Matej.
Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds.
European Journal of Medicinal Chemistry, 2019, 179, 109-112;
https://www.sciencedirect.com/science/article/pii/S0223523419305586, doi: 10.1016/j.ejmech.2019.06.030
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2019
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4.
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SOSIČ, Izidor, ANDERLUH, Marko, SOVA, Matej, GOBEC, Martina, MLINARIČ-RAŠČAN, Irena, DEROUAUX, Adeline, AMOROSO, Ana, TERRAK, Mohammed, BREUKINK, Eefjan, GOBEC, Stanislav:
Structure-activity relationships of novel tryptamine-based inhibitors of bacterial transglycosylase.
Journal of Medicinal Chemistry, 2015, 58(24), 9712-9721;
http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01482, doi: 10.1021/acs.jmedchem.5b01482
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2015
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5.
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FRLAN, Rok, SOVA, Matej, GOBEC, Stanislav, STAVBER, Gaj, ČASAR, Zdenko:
Cobalt-catalyzed cross-coupling of Grignards with allylic and vinylic bromides : use of sarcosine as a natural ligand.
Journal of Organic Chemistry, 2015, 80(15), 7803-7809;
http://pubs.acs.org/doi/full/10.1021/acs.joc.5b01156, doi: 10.1021/acs.joc.5b01156
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2015
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Patents:
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1.
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Disubtituted azetidines, pyrrolidines, piperidines and azepanes as inhibitors of monoamine oxidase b for the treatment of neurodegenerative diseases = Disubstituierte Azetidine, Pyrrolidine, Piperidine und Azepane als Inhibitoren der Monoaminoxidase b zur behandlung von neurodegenerativen Erkrankungen = Azétidines, pyrrolidines, pipéridines et azépanes di-substitués en tant qu'inhibiteurs de monoamine oxydase b pour le traitement de maladies neurodégénératives :
European patent specification EP 3 426 634 B1, 2020-01-22. München: European Patent Office, 2020. https://worldwide.espacenet.com/patent/search/family/059930365/publication/EP3426634A1?q=EP3426634B1.
Inventorji: KNEZ, Damijan, SOVA, Matej, GOBEC, Stanislav.
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2020
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2.
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Preparation of sitagliptin intermediates, United States US 9,174,930 B2, Issued November 2015
Additional granted patents in WO12136383 A2 patent family: CN 103608328 B, 10. 02. 2016
Inventorji: Matej Sova, Zdenko Časar, Gaj Stavber
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2016
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3.
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Process for the synthesis of ezetimibe and intermediates therefor, Japan JP 5735913 B2, Issued April 2015
Additional granted patents in WO 10012775 A1 patent family: CN 102112430 B, 28. 05. 2014, AU 2009275904 BB, 14. 08. 2014
Inventorji: Janez Mravljak, Matej Sova, Andreja Kovač, Stanislav Gobec, Zdenko Časar
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2015
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4.
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SOVA, Matej, KNEZ, Damijan, GOBEC, Stanislav. (Z)-vinil substituirani piperidini kot zaviralci monoamin oksidaze a za terapijo depresije in drugih afektivnih motenj , SI25271 (A), 2018-03-30. Ljubljana: Urad RS za intelektualno lastnino, 2018.
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2018
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5.
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KNEZ, Damijan, SOVA, Matej, GOBEC, Stanislav. Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni , SI25272 (A), 2018-03-30. Ljubljana: Urad RS za intelektualno lastnino, 2018.
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2018
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6.
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ŠVAJGER, Urban, BRUS, Boris, GOBEC, Stanislav, TURK, Samo, SOVA, Matej, HODNIK, Vesna, ANDERLUH, Gregor. Antagonisti toll-u podobnega receptorja 4 (TLR-4), odkriti z virtualnim rešetanjem , SI24316 (A), 2014-09-30, Ljubljana: Urad RS za intelektualno lastnino, 2014.
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2014
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Citations and the most cited scientific papers:
Wos: 865 citations (764 pure citations), Scopus 913 (805 pure citations) – date: 20.05.2020
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1.
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SOVA, Matej.
Antioxidant and antimicrobial activities of cinnamic acid derivatives.
Mini Reviews in Medicinal Chemistry, 2012, 12(8), 749-767.
http://www.benthamscience.com/contents-JCode-MRMC-Vol-00000012-Iss-00000008.htm.
Wos: 159 citations (156 pure citations), Scopus 168 (165pure citations)
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2012
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2.
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BARRETEAU, Hélène, KOVAČ, Andreja, BONIFACE, Audrey, SOVA, Matej, GOBEC, Stanislav, BLANOT, Didier. Cytoplasmic steps of peptidoglycan biosynthesis.
FEMS Microbiology Reviews, 2008, 32(2), 168-207.
doi: 10.1111/j.1574-6976.2008.00104.x.
Wos: 325 citations (278 pure citations), Scopus 354 (305 pure citations)
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2008
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