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General:
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E-mail:
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matej.sova@ffa.uni-lj.si
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Phone:
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+386 1 47 69 556
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Fax:
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+386 1 42 58 031
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Education:
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1998-2004
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Uniform master’s study programme Pharmacy (Master of Pharmacy)
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2004-2009
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Doctoral study programme Biomedicine, fields Pharmacy (Ph.D.) - young researcher at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2010
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Postdoctoral researcher at the Department of Medicinal Chemistry, School of Pharmacy, Leeds, UK
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Academic titles (ranks):
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2004-2012
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Assistant at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2012-2019
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Assistant Professor at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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2019-present
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Associate Professor at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia
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Research interests:
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- design, synthesis and evaluation of small-molecule enzyme inhibitors and modulators of receptors
- indoleamine 2,3-dioxygenase inhibitors
- Toll-like receptors modulators
- inhibitors of bacterial cell wall biosynthesis (inhibitors of Mur enzymes, glycosyl transferase, Upps)
- monoamine oxidase inhibitors
- antitumor agents
- antibacterial agents
- antimicotics
- cinnamic acid and derivatives
- cross-coupling reactions
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Expertise:
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- drug design and development
- organic chemistry, synthesis
- medicinal chemistry
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Contributions:
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- author or co-author of 47 in peer-reviewed journals
- author of 3 national and 3 international patents
- collaborative research between Faculty of Pharmacy and Slovenian pharmaceutical industry(Lek d.d., Krka d.d.); joint patent applications and patents
- reviewer for several journals from Wiley, Elsevier journals, American Chemical Society, MDPI, Wiley, Springer
- participation in numerous international scientific meetings and conferences
- editorial contributions:
1. Review Editor for Molecular Innate Immunity in Frontiers in Immunology (impact factor 7.561)
2. Frontiers Topic Editor in Frontiers in Pharmacology (IF 5.810)
3. Topic Editor for MDPI journal Molecules (IF 4.411)
4. Guest Editor for two special issues in Molecules
5. Editor in Aquatic Animal Reports
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Student supervision:
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- 5 undergraduate students
- more than 35 Master students
- 3 PhD students (Kaja Rožman 2014-2018, Ana Dolšak 2017-2021, Nika Strašek 2020-present)
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Prizes and awards:
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- 2016: Chamber of Commerce and Industry of Slovenia Golden Innovation Award (Slovenian National Award)
- 2016: Chamber of Commerce and Industry Golden Innovation Award – main Slovenian region (Ljubljana)
- 2009: Krka Pharmaceutical Company Award for doctoral thesis “Design and synthesis of hydroxyethylamines as inhibitors of peptidoglycan biosynthesis”
- 2004: The Faculty of Pharmacy Prešeren Award for research work
- 2001 and 2003: Faculty commendations for the best students of the year)
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Research projects:
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- 2022-2024: PI of international bilateral project with USA BI-US/22-24-053: “Optimization, synthesis and biological evaluation of novel Toll-like receptors 7 and 8 modulators”
- 2019-2020: PI of international bilateral project with Russia BI-RU/19-20-040: “Investigation of influence of cinnamic acid derivatives on prion proteins and alpha-synuclein”
- 2018-2020: PI of international bilateral project with USA BI-US/18-20-087: “Computer-aided design and structure-activity relationship study of TLR7 and TLR8 modulators as potential anticancer agents”
- 2017: PI of the research project with Lek pharmaceuticals d.d. "The synthesis of sitagliptin impurities”
- 2007-present: main researcher in industrial research projects with Krka d.d. (resulted in paper J. Enzyme Inhib. Med. Chem. 2007;22(1):29) and Lek d.d. (5 projects, 3 papers in high-ranked journals and 3 international patents):
- 2005-2010: main researcher in European project EUR-INTAFAR: Inhibition of new targets for fighting antibiotic resistance"; Integrated FP6 EU project; LSHM-CT-2004-512138
2004-present: member of the research programme P1-0208 »Medicinal chemistry: drug design, synthesis and evaluation«)
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Lectures at international conferences or universities:
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- 23.7.2019: lecture “The research on Toll-like receptors and indolamine 2,3-dioxygenase - promising targets for cancer immunotherapy” at University of Minnesota, College of Pharmacy, Minneapolis, Minnesota, USA (bilateral project BI-US/18-20-087)2011: oral presentation at 7th Joint Meeting on Medicinal Chemistry in Catania, Italy
- 5.6.2019: lecture “Biological activities and research on cinnamic acid derivatives” at Lomonosov Moscow State University, A. N. Belozersky Research Institute of Physico-Chemical Biology, Moscow, Russia (bilateral project BI-RU/19-20-040)
- 29.6.2017: key-note lecture at 10th Joint Meeting on Medicinal Chemistry in Dubrovnik, Croatia
- 2017: lectures at Sapienza Universita di Roma, Italy (Erasmus+ staff mobility project)
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PUBLICATIONS
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47 publications in peer-reviewed journals
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5 recent and/or most important papers:
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1. Dolšak A, Gobec S, SOVA M. Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets. Pharmacology & Therapeutics, 2021, 221, 1-23. IF = 10.557, rank: 7th among 270 journals in the section »Pharmacology&Pharmacy«
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2021
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2. Dolšak A, Šribar D, et al. SOVA M, Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators : synthesis, biological evaluation and structure-activity relationships. European Jounrnal of Medicinal Chemistry 2021, 225, 1-17. IF = 6.514, rank: 5th among 63 journals in the section »Chemistry, Medicinal«
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2021
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3. Dolšak A, Bratkovič T, Mlinarič L, Ogorevc E, Švajger U, Gobec S, SOVA M. Novel selective IDO1 inhibitors with isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. Pharmaceuticals 2021, 14, 1-18.
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2021
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4. Knez D, Colettis N, Iacovio LG, SOVA M, Pišlar A, Konc J, Lešnik S, Higgs J, Kamecki F, Mangialavori I, Dolšak A, Žakelj S, Trontelj J, Kos J, Binda C, Marder MN, Gobec . Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B. Journal of Medicinal Chemistry 2020, 63(3), 1361-1387. IF = 6.054; rank: 3rd among 61 journals in the section »Chemistry, Medicinal«
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2020
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5. Dolšak A, Švajger U, Lešnik S, Konc J, Gobec S, SOVA M. Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds. European Journal of Medicinal Chemistry 2019, 179, 109-112.
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2019
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Patents:
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1.Disubtituted azetidines, pyrrolidines, piperidines and azepanes as inhibitors of monoamine oxidase b for the treatment of neurodegenerative diseases = Disubstituierte Azetidine, Pyrrolidine, Piperidine und Azepane als Inhibitoren der Monoaminoxidase b zur behandlung von neurodegenerativen Erkrankungen = Azétidines, pyrrolidines, pipéridines et azépanes di-substitués en tant qu'inhibiteurs de monoamine oxydase b pour le traitement de maladies neurodégénératives :
European patent specification EP 3 426 634 B1, 2020-01-22. München: European Patent Office, 2020. https://worldwide.espacenet.com/patent/search/family/059930365/publication/EP3426634A1?q=EP3426634B1.
Inventors: KNEZ, Damijan, SOVA, Matej, GOBEC, Stanislav.
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2020
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2. Preparation of sitagliptin intermediates, United States US 9,174,930 B2, Issued November 2015
Additional granted patents in WO12136383 A2 patent family: CN 103608328 B, 10. 02. 2016
Inventors: Matej Sova, Zdenko Časar, Gaj Stavber
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2016
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3. Process for the synthesis of ezetimibe and intermediates therefor, Japan JP 5735913 B2, Issued April 2015
Additional granted patents in WO 10012775 A1 patent family: CN 102112430 B, 28. 05. 2014, AU 2009275904 BB, 14. 08. 2014
Inventors: Janez Mravljak, Matej Sova, Andreja Kovač, Stanislav Gobec, Zdenko Časar
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2015
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4. SOVA, Matej, KNEZ, Damijan, GOBEC, Stanislav. (Z)-vinil substituirani piperidini kot zaviralci monoamin oksidaze a za terapijo depresije in drugih afektivnih motenj , SI25271 (A), 2018-03-30. Ljubljana: Urad RS za intelektualno lastnino, 2018.
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2018
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5. KNEZ, Damijan, SOVA, Matej, GOBEC, Stanislav. Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni , SI25272 (A), 2018-03-30. Ljubljana: Urad RS za intelektualno lastnino, 2018.
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2018
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6. ŠVAJGER, Urban, BRUS, Boris, GOBEC, Stanislav, TURK, Samo, SOVA, Matej, HODNIK, Vesna, ANDERLUH, Gregor. Antagonisti toll-u podobnega receptorja 4 (TLR-4), odkriti z virtualnim rešetanjem , SI24316 (A), 2014-09-30, Ljubljana: Urad RS za intelektualno lastnino, 2014.
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2014
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Citations and the most cited scientific papers:
Hirsch index: 22 (Google Scholar), 16 (h10)
Wos: 1272 citations (1142 pure citations), Scopus 1364 (1225 pure citations) – date: 07.03.2022
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1. SOVA, Matej. Antioxidant and antimicrobial activities of cinnamic acid derivatives.
Mini Reviews in Medicinal Chemistry, 2012, 12(8), 749-767.
http://www.benthamscience.com/contents-JCode-MRMC-Vol-00000012-Iss-00000008.htm.
Wos: 246 citations (239 pure citations), Scopus 254 (247 pure citations)
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2012
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2. BARRETEAU, Hélène, KOVAČ, Andreja, BONIFACE, Audrey, SOVA, Matej, GOBEC, Stanislav, BLANOT, Didier. Cytoplasmic steps of peptidoglycan biosynthesis.
FEMS Microbiology Reviews, 2008, 32(2), 168-207.
doi: 10.1111/j.1574-6976.2008.00104.x.
Wos: 401 citations (353 pure citations), Scopus 442 (391 pure citations)
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2008
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