| RESEARCH INTEREST:
- Synthesis of active pharmaceutical ingredients (APIs):
Total synthesis of APIs, asymmetric synthesis of APIs, catalysis in the synthesis of APIs (organocatalysis, organometallic catalysis in enzymatic catalysis), heterocyclic chemistry
Prediction and studies on degradations of APIs
Methods of LC chromatography in NMR for evaluation of quality of APIs and drug products
Synthesis and characterization of novel solid forms of APIs (polymorphs, solvates and co-crystals)
BIBLIOGRAPHY:
published 63 articles in SCI journals (in 58 articles as first or corresponding author). Representative articles:
Lactone Pathway to Statins Utilizing the Wittig Reaction. The Synthesis of Rosuvastatin, J. Org. Chem., 2010, 75, 6681–6684. http://pubs.acs.org/doi/10.1021/jo101050z
Iridium-Catalyzed Chemoselective and Enantioselective Hydrogenation of (1-Chloro-1-Alkenyl) Boronic Esters, Angew. Chem. Int. Ed., 2012, 51, 1014–1018. http://onlinelibrary.wiley.com/doi/10.1002/anie.201106262/full
Application of Flow Photochemical Bromination in the Synthesis of a 5-Bromomethylpyrimidine Precursor of Rosuvastatin: Improvement of Productivity and Product Purity, Org. Process Res. Dev., 2013, 17, 145–151. http://pubs.acs.org/doi/10.1021/op300248y
Cobalt-Catalyzed Cross-Coupling of Grignards with Allylic and Vinylic Bromides: Use of Sarcosine as a Natural Ligand, J. Org. Chem., 2015, 80, 7803–7809. http://pubs.acs.org/doi/10.1021/acs.joc.5b01156
Development of Concise Two-step Catalytic Approach Towards Lasofoxifene Precursor Nafoxidine, Bioorg. Med. Chem., 2018, 26, 2691–2697. https://www.sciencedirect.com/science/article/pii/S0968089618303353
Understanding and Kinetic Modeling of Complex Degradation Pathways in the Solid Dosage Form: The Case of Saxagliptin, Pharmaceutics 2019, 11, 452. https://www.mdpi.com/1999-4923/11/9/452
Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates, Pharmaceutics 2020, 12, 342. https://www.mdpi.com/1999-4923/12/4/342
Synthetic Approaches to Contemporary Drugs that Contain the Cyclopropyl Moiety, Synthesis 2020, 52, 1315–1345, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1690058
Concise Six-Step Asymmetric Approach to Ramelteon from an Acetophenone Derivative Using Ir, Rh, Cu, and Ni Catalysis. J. Org. Chem. 2022, 87, 4, 2129–2135. https://doi.org/10.1021/acs.joc.1c01614
Primary trifluoroborate-iminiums enable facile access to chiral α-aminoboronic acids via Ru-catalyzed asymmetric hydrogenation and simple hydrolysis of the trifluoroborate moiety. Chem. Sci. 2022,13, 2946–2953. https://doi.org/10.1039/D1SC07065G
>80 granted international patents (EU, US, JP, CN, CA)
Editor and co-author of monograph entitled »Synthesis of Heterocycles in Contemporary Medicinal Chemistry« Springer’s »Topics in Heterocyclic Chemistry« series (http://www.springer.com/gp/book/9783319399157)
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| 2010 – present time: reviewer/referee for the publishing houses:
American Chemical Society Publications, USA (journals: ACS Omega, Organic Process Research & Development, Industrial & Engineering Chemistry Research, The Journal of Organic Chemistry, Organometallics, Organic Letters, and The Journal of the American Chemical Society)
Wiley-VCH, Germany (journals: Chirality, Applied Organometallic Chemistry, European Journal of Organic Chemistry, Chemistry - A European Journal, ChemCatChem, ChemSusChem, Advanced Synthesis & Catalysis)
Thieme, Germany (journals: Synlett in Synthesis)
Royal Society of Chemistry, UK (journal: Organic Chemistry Frontiers)
and some other journals
2021 – present time: member of General committee at Slovenian Chemical Society
2015 – present time: member of Expert group 10D at European Directorate for the Quality of Medicines & HealthCare (EDQM), Strasbourg, France
2009 – 2017: member of »Sandoz Scientific Core Team« & »Sandoz Development, Science and Systems Committee«
2011 – 2017: Chair and member of Scientific Committee »Regional BioCamp Lek«
2015 – 2017: member of the working group for preparation of occupation profiles as well as competently conceived occupational standards in the area of chemistry at Institute of the Republic of Slovenia for Vocational Education and Training
2016 – 2018: vice-president of council of the Slovenian Science Foundation
2018 – 2019: president of council of the Slovenian Science Foundation and member of the board of management of the Slovenian Science Foundation
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